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Mechanistic Investigations of Metallo-β-lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition*.
ChemMedChem. 2021 May 18;16(10):1651-1659. doi: 10.1002/cmdc.202100042. Epub 2021 Mar 3.
ChemMedChem. 2021.
PMID: 33534956
Free PMC article.
Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1.
Tehrani KHME, Fu H, Brüchle NC, Mashayekhi V, Prats Luján A, van Haren MJ, Poelarends GJ, Martin NI.
Tehrani KHME, et al. Among authors: bruchle nc.
Chem Commun (Camb). 2020 Mar 10;56(20):3047-3049. doi: 10.1039/d0cc00356e.
Chem Commun (Camb). 2020.
PMID: 32048688
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Cephalosporin Prodrug Inhibitors Overcome Metallo-β-Lactamase Driven Antibiotic Resistance.
van Haren MJ, Tehrani KHME, Kotsogianni I, Wade N, Brüchle NC, Mashayekhi V, Martin NI.
van Haren MJ, et al. Among authors: bruchle nc.
Chemistry. 2021 Feb 19;27(11):3806-3811. doi: 10.1002/chem.202004694. Epub 2021 Jan 8.
Chemistry. 2021.
PMID: 33237604
Free PMC article.
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Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem.
Tehrani KHME, Brüchle NC, Wade N, Mashayekhi V, Pesce D, van Haren MJ, Martin NI.
Tehrani KHME, et al. Among authors: bruchle nc.
ACS Infect Dis. 2020 Jun 12;6(6):1366-1371. doi: 10.1021/acsinfecdis.9b00459. Epub 2020 Apr 3.
ACS Infect Dis. 2020.
PMID: 32227874
Free PMC article.
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Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases.
Tehrani KHME, Wade N, Mashayekhi V, Brüchle NC, Jespers W, Voskuil K, Pesce D, van Haren MJ, van Westen GJP, Martin NI.
Tehrani KHME, et al. Among authors: bruchle nc.
J Med Chem. 2021 Jul 8;64(13):9141-9151. doi: 10.1021/acs.jmedchem.1c00362. Epub 2021 Jun 28.
J Med Chem. 2021.
PMID: 34182755
Free PMC article.
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Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy.
Al Ayed K, Ballantine RD, Hoekstra M, Bann SJ, Wesseling CMJ, Bakker AT, Zhong Z, Li YX, Brüchle NC, van der Stelt M, Cochrane SA, Martin NI.
Al Ayed K, et al. Among authors: bruchle nc.
Chem Sci. 2022 Feb 23;13(12):3563-3570. doi: 10.1039/d2sc00143h. eCollection 2022 Mar 24.
Chem Sci. 2022.
PMID: 35432860
Free PMC article.
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Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant Escherichia coli using high cell density cultivation.
Bartling B, Brüchle NC, Rehfeld JS, Boßmann D, Fiebig T, Litschko C, Fohrer J, Gerardy-Schahn R, Scheper T, Beutel S.
Bartling B, et al. Among authors: bruchle nc.
Biotechnol Rep (Amst). 2020 Nov 18;28:e00562. doi: 10.1016/j.btre.2020.e00562. eCollection 2020 Dec.
Biotechnol Rep (Amst). 2020.
PMID: 33304838
Free PMC article.
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