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Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, Uytterhoeven V, Verstreken P. Largo-Barrientos P, et al. Neuron. 2021 Mar 3;109(5):767-777.e5. doi: 10.1016/j.neuron.2020.12.016. Epub 2021 Jan 19. Neuron. 2021. PMID: 33472038 Free PMC article.
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.
Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A. Huang Y, et al. Sci Transl Med. 2015 Oct 14;7(309):309ra164. doi: 10.1126/scitranslmed.aab3492. Sci Transl Med. 2015. PMID: 26468326
Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology.
Sierksma A, Lu A, Salta E, Vanden Eynden E, Callaerts-Vegh Z, D'Hooge R, Blum D, Buée L, Fiers M, De Strooper B. Sierksma A, et al. Mol Neurodegener. 2018 Oct 12;13(1):54. doi: 10.1186/s13024-018-0285-1. Mol Neurodegener. 2018. PMID: 30314521 Free PMC article.
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.
Poppe L, Rué L, Timmers M, Lenaerts A, Storm A, Callaerts-Vegh Z, Courtand G, de Boer A, Smolders S, Van Damme P, Van Den Bosch L, D'Hooge R, De Strooper B, Robberecht W, Lemmens R. Poppe L, et al. Alzheimers Res Ther. 2019 Dec 12;11(1):102. doi: 10.1186/s13195-019-0554-4. Alzheimers Res Ther. 2019. PMID: 31831046 Free PMC article.
70 results