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Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma.
Agliardi G, Liuzzi AR, Hotblack A, De Feo D, Núñez N, Stowe CL, Friebel E, Nannini F, Rindlisbacher L, Roberts TA, Ramasawmy R, Williams IP, Siow BM, Lythgoe MF, Kalber TL, Quezada SA, Pule MA, Tugues S, Straathof K, Becher B. Agliardi G, et al. Among authors: nunez n. Nat Commun. 2021 Jan 19;12(1):444. doi: 10.1038/s41467-020-20599-x. Nat Commun. 2021. PMID: 33469002 Free PMC article.
Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy.
Martí i Líndez AA, Dunand-Sauthier I, Conti M, Gobet F, Núñez N, Hannich JT, Riezman H, Geiger R, Piersigilli A, Hahn K, Lemeille S, Becher B, De Smedt T, Hugues S, Reith W. Martí i Líndez AA, et al. Among authors: nunez n. JCI Insight. 2019 Nov 21;4(24):e132975. doi: 10.1172/jci.insight.132975. JCI Insight. 2019. PMID: 31751318 Free PMC article.
Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas.
Aslan K, Turco V, Blobner J, Sonner JK, Liuzzi AR, Núñez NG, De Feo D, Kickingereder P, Fischer M, Green E, Sadik A, Friedrich M, Sanghvi K, Kilian M, Cichon F, Wolf L, Jähne K, von Landenberg A, Bunse L, Sahm F, Schrimpf D, Meyer J, Alexander A, Brugnara G, Röth R, Pfleiderer K, Niesler B, von Deimling A, Opitz C, Breckwoldt MO, Heiland S, Bendszus M, Wick W, Becher B, Platten M. Aslan K, et al. Nat Commun. 2020 Feb 18;11(1):931. doi: 10.1038/s41467-020-14642-0. Nat Commun. 2020. PMID: 32071302 Free PMC article.
Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy.
Georganaki M, Ramachandran M, Tuit S, Núñez NG, Karampatzakis A, Fotaki G, van Hooren L, Huang H, Lugano R, Ulas T, Kaunisto A, Holland EC, Ellmark P, Mangsbo SM, Schultze J, Essand M, Tugues S, Dimberg A. Georganaki M, et al. Oncoimmunology. 2020 Mar 9;9(1):1730538. doi: 10.1080/2162402X.2020.1730538. eCollection 2020. Oncoimmunology. 2020. PMID: 32231867 Free PMC article.
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients.
Núñez NG, Tosello Boari J, Ramos RN, Richer W, Cagnard N, Anderfuhren CD, Niborski LL, Bigot J, Meseure D, De La Rochere P, Milder M, Viel S, Loirat D, Pérol L, Vincent-Salomon A, Sastre-Garau X, Burkhard B, Sedlik C, Lantz O, Amigorena S, Piaggio E. Núñez NG, et al. Nat Commun. 2020 Jun 29;11(1):3272. doi: 10.1038/s41467-020-17046-2. Nat Commun. 2020. PMID: 32601304 Free PMC article.
297 results