Scannevin RH - Search Results

1

Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses.

Wipke BT, Hoepner R, Strassburger-Krogias K, Thomas AM, Gianni D, Szak S, Brennan MS, Pistor M, Gold R, Chan A, Scannevin RH. Wipke BT, et al. Among authors: scannevin rh. Neurol Neuroimmunol Neuroinflamm. 2021 Jan 19;8(2):e950. doi: 10.1212/NXI.0000000000000950. Print 2021 Mar. Neurol Neuroimmunol Neuroinflamm. 2021. PMID: 33468560 Free PMC article.

2

Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation.

Reick C, Ellrichmann G, Thöne J, Scannevin RH, Saft C, Linker RA, Gold R. Reick C, et al. Among authors: scannevin rh. Exp Neurol. 2014 Jul;257:50-6. doi: 10.1016/j.expneurol.2014.04.003. Epub 2014 Apr 13. Exp Neurol. 2014. PMID: 24731948

3

Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.

Brennan MS, Matos MF, Li B, Hronowski X, Gao B, Juhasz P, Rhodes KJ, Scannevin RH. Brennan MS, et al. Among authors: scannevin rh. PLoS One. 2015 Mar 20;10(3):e0120254. doi: 10.1371/journal.pone.0120254. eCollection 2015. PLoS One. 2015. PMID: 25793262 Free PMC article.

4

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.

Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS. Schulze-Topphoff U, et al. Among authors: scannevin rh. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4777-82. doi: 10.1073/pnas.1603907113. Epub 2016 Apr 13. Proc Natl Acad Sci U S A. 2016. PMID: 27078105 Free PMC article.

5

The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes.

Brennan MS, Matos MF, Richter KE, Li B, Scannevin RH. Brennan MS, et al. Among authors: scannevin rh. Sci Rep. 2017 Feb 9;7:42054. doi: 10.1038/srep42054. Sci Rep. 2017. PMID: 28181536 Free PMC article.

6

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R. Linker RA, et al. Among authors: scannevin rh. Brain. 2011 Mar;134(Pt 3):678-92. doi: 10.1093/brain/awq386. Brain. 2011. PMID: 21354971

7

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms.

Brennan MS, Patel H, Allaire N, Thai A, Cullen P, Ryan S, Lukashev M, Bista P, Huang R, Rhodes KJ, Scannevin RH. Brennan MS, et al. Among authors: scannevin rh. Antioxid Redox Signal. 2016 Jun 20;24(18):1058-71. doi: 10.1089/ars.2015.6622. Epub 2016 Apr 28. Antioxid Redox Signal. 2016. PMID: 26980071

8

Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments.

Peng H, Li H, Sheehy A, Cullen P, Allaire N, Scannevin RH. Peng H, et al. Among authors: scannevin rh. J Neuroimmunol. 2016 Oct 15;299:35-44. doi: 10.1016/j.jneuroim.2016.08.006. Epub 2016 Aug 5. J Neuroimmunol. 2016. PMID: 27725119

9

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.

Scannevin RH, Chollate S, Brennan MS, Snodgrass-Belt PA, Peng H, Xu L, Jung MY, Bussiere T, Arastu MF, Talreja T, Xin Z, Dunstan RW, Fahrer D, Rohde E, Dunah AW, Wang J, Kumaravel G, Taveras AG, Moore Arnold H, Rhodes KJ. Scannevin RH, et al. Neuropharmacology. 2016 Apr;103:57-68. doi: 10.1016/j.neuropharm.2015.12.006. Epub 2015 Dec 12. Neuropharmacology. 2016. PMID: 26690893

10

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner.

Gillard GO, Collette B, Anderson J, Chao J, Scannevin RH, Huss DJ, Fontenot JD. Gillard GO, et al. Among authors: scannevin rh. J Neuroimmunol. 2015 Jun 15;283:74-85. doi: 10.1016/j.jneuroim.2015.04.006. Epub 2015 Apr 23. J Neuroimmunol. 2015. PMID: 26004161 Free article.

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