Ohkubo T - Search Results

1

Radiosynthesis of ¹⁸F-fluoroethylated tracers via a simplified one-pot ¹⁸F-fluoroethylation method using [¹⁸F]fluoroethyl tosylate.

Kawamura K, Kumata K, Mori W, Fujinaga M, Kurihara Y, Ogawa M, Ohkubo T, Furutsuka K, Hashimoto H, Nengaki N, Zhang MR. Kawamura K, et al. Among authors: ohkubo t. Appl Radiat Isot. 2021 Mar;169:109571. doi: 10.1016/j.apradiso.2020.109571. Epub 2020 Dec 26. Appl Radiat Isot. 2021. PMID: 33412382

2

Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a).

Kawamura K, Fujinaga M, Shimoda Y, Yamasaki T, Zhang Y, Hatori A, Xie L, Wakizaka H, Kumata K, Ohkubo T, Kurihara Y, Ogawa M, Nengaki N, Zhang MR. Kawamura K, et al. Among authors: ohkubo t. Nucl Med Biol. 2017 Sep;52:49-56. doi: 10.1016/j.nucmedbio.2017.06.002. Epub 2017 Jun 10. Nucl Med Biol. 2017. PMID: 28628775

3

Comparison between [¹⁸F]fluorination and [¹⁸F]fluoroethylation reactions for the synthesis of the PDE10A PET radiotracer [¹⁸F]MNI-659.

Mori W, Takei M, Furutsuka K, Fujinaga M, Kumata K, Muto M, Ohkubo T, Hashimoto H, Tamagnan G, Higuchi M, Kawamura K, Zhang MR. Mori W, et al. Among authors: ohkubo t. Nucl Med Biol. 2017 Dec;55:12-18. doi: 10.1016/j.nucmedbio.2017.08.002. Epub 2017 Aug 25. Nucl Med Biol. 2017. PMID: 28972915

4

Automated Synthesis of (rac)-, (R)-, and (S)-[¹⁸ F]Epifluorohydrin and Their Application for Developing PET Radiotracers Containing a 3-[¹⁸ F]Fluoro-2-hydroxypropyl Moiety.

Fujinaga M, Ohkubo T, Yamasaki T, Zhang Y, Mori W, Hanyu M, Kumata K, Hatori A, Xie L, Nengaki N, Zhang MR. Fujinaga M, et al. Among authors: ohkubo t. ChemMedChem. 2018 Aug 20;13(16):1723-1731. doi: 10.1002/cmdc.201800359. Epub 2018 Jul 25. ChemMedChem. 2018. PMID: 30043406

5

[¹⁸F]DAA1106: Automated radiosynthesis using spirocyclic iodonium ylide and preclinical evaluation for positron emission tomography imaging of translocator protein (18 kDa).

Kumata K, Zhang Y, Fujinaga M, Ohkubo T, Mori W, Yamasaki T, Hanyu M, Xie L, Hatori A, Zhang MR. Kumata K, et al. Among authors: ohkubo t. Bioorg Med Chem. 2018 Sep 15;26(17):4817-4822. doi: 10.1016/j.bmc.2018.08.017. Epub 2018 Aug 12. Bioorg Med Chem. 2018. PMID: 30166255

6

Synthesis of two novel [¹⁸F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain.

Fujinaga M, Kumata K, Zhang Y, Hatori A, Yamasaki T, Mori W, Ohkubo T, Xie L, Nengaki N, Zhang MR. Fujinaga M, et al. Among authors: ohkubo t. Org Biomol Chem. 2018 Sep 26;16(37):8325-8335. doi: 10.1039/c8ob01700j. Org Biomol Chem. 2018. PMID: 30206613

7

Development of 2-(2-(3-(4-([¹⁸F]Fluoromethoxy- d₂)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione for Positron-Emission-Tomography Imaging of Phosphodiesterase 10A in the Brain.

Mori W, Yamasaki T, Fujinaga M, Ogawa M, Zhang Y, Hatori A, Xie L, Kumata K, Wakizaka H, Kurihara Y, Ohkubo T, Nengaki N, Zhang MR. Mori W, et al. Among authors: ohkubo t. J Med Chem. 2019 Jan 24;62(2):688-698. doi: 10.1021/acs.jmedchem.8b01366. Epub 2018 Dec 19. J Med Chem. 2019. PMID: 30516998

8

Radiosynthesis and in vivo evaluation of ¹¹C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors.

Kawamura K, Mori W, Fujinaga M, Yamasaki T, Zhang Y, Wakizaka H, Hatori A, Xie L, Kumata K, Ohkubo T, Kurihara Y, Ogawa M, Nengaki N, Zhang MR. Kawamura K, et al. Among authors: ohkubo t. EJNMMI Radiopharm Chem. 2019 Feb 18;4(1):4. doi: 10.1186/s41181-019-0056-5. EJNMMI Radiopharm Chem. 2019. PMID: 31659508 Free PMC article.

9

Simultaneous measurements of the molar radioactivity, radiochemical purity and chemical impurity in the [¹¹C]choline injection using radio-HPLC with a corona-charged aerosol detector.

Hashimoto H, Furutsuka K, Kawamura K, Ohkubo T, Ogawa M, Kurihara Y, Nengaki N, Zhang MR. Hashimoto H, et al. Among authors: ohkubo t. Appl Radiat Isot. 2020 Aug;162:109192. doi: 10.1016/j.apradiso.2020.109192. Epub 2020 Apr 27. Appl Radiat Isot. 2020. PMID: 32501231

10

Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [¹⁸ F]PM-PBB3 for clinical applications.

Kawamura K, Hashimoto H, Furutsuka K, Ohkubo T, Fujishiro T, Togashi T, Arashi D, Sakai T, Muto M, Ogawa M, Kurihara Y, Nengaki N, Takei M, Nemoto K, Higuchi M, Zhang MR. Kawamura K, et al. Among authors: ohkubo t. J Labelled Comp Radiopharm. 2021 Mar;64(3):109-119. doi: 10.1002/jlcr.3890. Epub 2020 Nov 7. J Labelled Comp Radiopharm. 2021. PMID: 33067819

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