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Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo.
Collin N, Assumpção TC, Mizurini DM, Gilmore DC, Dutra-Oliveira A, Kotsyfakis M, Sá-Nunes A, Teixeira C, Ribeiro JM, Monteiro RQ, Valenzuela JG, Francischetti IM. Collin N, et al. Among authors: mizurini dm. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2185-98. doi: 10.1161/ATVBAHA.112.253906. Epub 2012 Jul 12. Arterioscler Thromb Vasc Biol. 2012. PMID: 22796577 Free PMC article.
Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.
Waisberg M, Molina-Cruz A, Mizurini DM, Gera N, Sousa BC, Ma D, Leal AC, Gomes T, Kotsyfakis M, Ribeiro JM, Lukszo J, Reiter K, Porcella SF, Oliveira CJ, Monteiro RQ, Barillas-Mury C, Pierce SK, Francischetti IM. Waisberg M, et al. Among authors: mizurini dm. PLoS Pathog. 2014 Sep 11;10(9):e1004338. doi: 10.1371/journal.ppat.1004338. eCollection 2014 Sep. PLoS Pathog. 2014. PMID: 25211214 Free PMC article.
In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus.
Assumpção TC, Ma D, Mizurini DM, Kini RM, Ribeiro JM, Kotsyfakis M, Monteiro RQ, Francischetti IM. Assumpção TC, et al. Among authors: mizurini dm. PLoS Negl Trop Dis. 2016 Jan 8;10(1):e0004298. doi: 10.1371/journal.pntd.0004298. eCollection 2016 Jan. PLoS Negl Trop Dis. 2016. PMID: 26745503 Free PMC article.
Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis.
Assumpção TC, Mizurini DM, Ma D, Monteiro RQ, Ahlstedt S, Reyes M, Kotsyfakis M, Mather TN, Andersen JF, Lukszo J, Ribeiro JMC, Francischetti IMB. Assumpção TC, et al. Among authors: mizurini dm. Sci Rep. 2018 Mar 19;8(1):4806. doi: 10.1038/s41598-018-22780-1. Sci Rep. 2018. PMID: 29555911 Free PMC article.
22 results