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C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms.
Heydenreich N, Nolte MW, Göb E, Langhauser F, Hofmeister M, Kraft P, Albert-Weissenberger C, Brede M, Varallyay C, Göbel K, Meuth SG, Nieswandt B, Dickneite G, Stoll G, Kleinschnitz C. Heydenreich N, et al. Among authors: langhauser f. Stroke. 2012 Sep;43(9):2457-67. doi: 10.1161/STROKEAHA.112.660340. Epub 2012 Jun 28. Stroke. 2012. PMID: 22744646
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
Langhauser F, Göb E, Kraft P, Geis C, Schmitt J, Brede M, Göbel K, Helluy X, Pham M, Bendszus M, Jakob P, Stoll G, Meuth SG, Nieswandt B, McCrae KR, Kleinschnitz C. Langhauser F, et al. Blood. 2012 Nov 8;120(19):4082-92. doi: 10.1182/blood-2012-06-440057. Epub 2012 Aug 30. Blood. 2012. PMID: 22936662 Free PMC article.
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Göbel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H. Kleinschnitz C, et al. Among authors: langhauser f. Blood. 2013 Jan 24;121(4):679-91. doi: 10.1182/blood-2012-04-426734. Epub 2012 Nov 15. Blood. 2013. PMID: 23160472 Free PMC article.
Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.
Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG. Bittner S, et al. Among authors: langhauser f. Nat Med. 2013 Sep;19(9):1161-5. doi: 10.1038/nm.3303. Epub 2013 Aug 11. Nat Med. 2013. PMID: 23933981
Blocking of α4 integrin does not protect from acute ischemic stroke in mice.
Langhauser F, Kraft P, Göb E, Leinweber J, Schuhmann MK, Lorenz K, Gelderblom M, Bittner S, Meuth SG, Wiendl H, Magnus T, Kleinschnitz C. Langhauser F, et al. Stroke. 2014 Jun;45(6):1799-806. doi: 10.1161/STROKEAHA.114.005000. Epub 2014 Apr 17. Stroke. 2014. PMID: 24743435
C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation.
Albert-Weissenberger C, Mencl S, Schuhmann MK, Salur I, Göb E, Langhauser F, Hopp S, Hennig N, Meuth SG, Nolte MW, Sirén AL, Kleinschnitz C. Albert-Weissenberger C, et al. Among authors: langhauser f. Front Cell Neurosci. 2014 Sep 9;8:269. doi: 10.3389/fncel.2014.00269. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25249935 Free PMC article.
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