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Guidelines for the design and conduct of human clinical trials on ingestion-time differences - chronopharmacology and chronotherapy - of hypertension medications.
Hermida RC, Smolensky MH, Balan H, Castriotta RJ, Crespo JJ, Dagan Y, El-Toukhy S, Fernández JR, FitzGerald GA, Fujimura A, Geng YJ, Hermida-Ayala RG, Machado AP, Menna-Barreto L, Mojón A, Otero A, Rudic RD, Schernhammer E, Skarke C, Steen TY, Young ME, Zhao X. Hermida RC, et al. Among authors: otero a. Chronobiol Int. 2021 Jan;38(1):1-26. doi: 10.1080/07420528.2020.1850468. Epub 2020 Dec 20. Chronobiol Int. 2021. PMID: 33342316 Free PMC article. Clinical Trial.
Administration-time-dependent effects of hypertension treatment on ambulatory blood pressure in patients with chronic kidney disease.
Crespo JJ, Piñeiro L, Otero A, Castiñeira C, Ríos MT, Regueiro A, Mojón A, Lorenzo S, Ayala DE, Hermida RC; Hygia Project Investigators. Crespo JJ, et al. Among authors: otero a. Chronobiol Int. 2013 Mar;30(1-2):159-75. doi: 10.3109/07420528.2012.701459. Epub 2012 Oct 25. Chronobiol Int. 2013. PMID: 23098134 Clinical Trial.
Treatment-time regimen of hypertension medications significantly affects ambulatory blood pressure and clinical characteristics of patients with resistant hypertension.
Hermida RC, Ríos MT, Crespo JJ, Moyá A, Domínguez-Sardiña M, Otero A, Sánchez JJ, Mojón A, Fernández JR, Ayala DE; Hygia Project Investigators. Hermida RC, et al. Among authors: otero a. Chronobiol Int. 2013 Mar;30(1-2):192-206. doi: 10.3109/07420528.2012.701460. Epub 2012 Oct 25. Chronobiol Int. 2013. PMID: 23098160 Clinical Trial.
Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial.
Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE; Hygia Project Investigators. Hermida RC, et al. Among authors: otero a. Eur Heart J. 2020 Dec 21;41(48):4565-4576. doi: 10.1093/eurheartj/ehz754. Eur Heart J. 2020. PMID: 31641769 Clinical Trial.
The Hygia Project and Hygia Chronotherapy Trial: insights of we clinical investigators on the impact of the embedded continuing medical education on primary-care practice and improved patient cardiovascular health.
Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ. Crespo JJ, et al. Among authors: otero a. Chronobiol Int. 2020 May;37(5):759-766. doi: 10.1080/07420528.2020.1771357. Epub 2020 Jul 20. Chronobiol Int. 2020. PMID: 32684006
Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials.
Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Mojón A, Fernández JR, Hermida RC. Crespo JJ, et al. Among authors: otero a. Chronobiol Int. 2020 May;37(5):771-780. doi: 10.1080/07420528.2020.1781351. Epub 2020 Jul 20. Chronobiol Int. 2020. PMID: 32684071
Does Timing of Antihypertensive Medication Dosing Matter?
Hermida RC, Hermida-Ayala RG, Smolensky MH, Mojón A, Crespo JJ, Otero A, Ríos MT, Domínguez-Sardiña M, Fernández JR. Hermida RC, et al. Among authors: otero a. Curr Cardiol Rep. 2020 Aug 9;22(10):118. doi: 10.1007/s11886-020-01353-7. Curr Cardiol Rep. 2020. PMID: 32772186 Review.
706 results