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Guidelines for the design and conduct of human clinical trials on ingestion-time differences - chronopharmacology and chronotherapy - of hypertension medications.
Hermida RC, Smolensky MH, Balan H, Castriotta RJ, Crespo JJ, Dagan Y, El-Toukhy S, Fernández JR, FitzGerald GA, Fujimura A, Geng YJ, Hermida-Ayala RG, Machado AP, Menna-Barreto L, Mojón A, Otero A, Rudic RD, Schernhammer E, Skarke C, Steen TY, Young ME, Zhao X. Hermida RC, et al. Among authors: crespo jj. Chronobiol Int. 2021 Jan;38(1):1-26. doi: 10.1080/07420528.2020.1850468. Epub 2020 Dec 20. Chronobiol Int. 2021. PMID: 33342316 Free PMC article. Clinical Trial.
Treatment-time regimen of hypertension medications significantly affects ambulatory blood pressure and clinical characteristics of patients with resistant hypertension.
Hermida RC, Ríos MT, Crespo JJ, Moyá A, Domínguez-Sardiña M, Otero A, Sánchez JJ, Mojón A, Fernández JR, Ayala DE; Hygia Project Investigators. Hermida RC, et al. Among authors: crespo jj. Chronobiol Int. 2013 Mar;30(1-2):192-206. doi: 10.3109/07420528.2012.701460. Epub 2012 Oct 25. Chronobiol Int. 2013. PMID: 23098160 Clinical Trial.
Chronotherapy improves blood pressure control and reduces vascular risk in CKD.
Hermida RC, Ayala DE, Smolensky MH, Mojón A, Fernández JR, Crespo JJ, Moyá A, Ríos MT, Portaluppi F. Hermida RC, et al. Among authors: crespo jj. Nat Rev Nephrol. 2013 Jun;9(6):358-68. doi: 10.1038/nrneph.2013.79. Epub 2013 Apr 23. Nat Rev Nephrol. 2013. PMID: 23609565 Review.
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