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Synergistic and Antagonistic Drug Combinations against SARS-CoV-2.
Bobrowski T, Chen L, Eastman RT, Itkin Z, Shinn P, Chen CZ, Guo H, Zheng W, Michael S, Simeonov A, Hall MD, Zakharov AV, Muratov EN. Bobrowski T, et al. Among authors: chen l, chen cz. Mol Ther. 2021 Feb 3;29(2):873-885. doi: 10.1016/j.ymthe.2020.12.016. Epub 2020 Dec 15. Mol Ther. 2021. PMID: 33333292 Free PMC article.
Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro.
Bobrowski T, Chen L, Eastman RT, Itkin Z, Shinn P, Chen C, Guo H, Zheng W, Michael S, Simeonov A, Hall MD, Zakharov AV, Muratov EN. Bobrowski T, et al. Among authors: chen l, chen c. bioRxiv [Preprint]. 2020 Jun 30:2020.06.29.178889. doi: 10.1101/2020.06.29.178889. bioRxiv. 2020. PMID: 32637956 Free PMC article. Updated. Preprint.
Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Shamim K, Xu M, Hu X, Lee EM, Lu X, Huang R, Shah P, Xu X, Chen CZ, Shen M, Guo H, Chen L, Itkin Z, Eastman RT, Shinn P, Klumpp-Thomas C, Michael S, Simeonov A, Lo DC, Ming GL, Song H, Tang H, Zheng W, Huang W. Shamim K, et al. Among authors: chen l, chen cz. Bioorg Med Chem Lett. 2021 May 15;40:127906. doi: 10.1016/j.bmcl.2021.127906. Epub 2021 Mar 6. Bioorg Med Chem Lett. 2021. PMID: 33689873 Free PMC article.
High-Throughput Screening for Drug Combinations.
Shinn P, Chen L, Ferrer M, Itkin Z, Klumpp-Thomas C, McKnight C, Michael S, Mierzwa T, Thomas C, Wilson K, Guha R. Shinn P, et al. Among authors: chen l. Methods Mol Biol. 2019;1939:11-35. doi: 10.1007/978-1-4939-9089-4_2. Methods Mol Biol. 2019. PMID: 30848454
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening.
Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Lin GL, et al. Among authors: chen l. Sci Transl Med. 2019 Nov 20;11(519):eaaw0064. doi: 10.1126/scitranslmed.aaw0064. Sci Transl Med. 2019. PMID: 31748226 Free PMC article.
An OpenData portal to share COVID-19 drug repurposing data in real time.
Brimacombe KR, Zhao T, Eastman RT, Hu X, Wang K, Backus M, Baljinnyam B, Chen CZ, Chen L, Eicher T, Ferrer M, Fu Y, Gorshkov K, Guo H, Hanson QM, Itkin Z, Kales SC, Klumpp-Thomas C, Lee EM, Michael S, Mierzwa T, Patt A, Pradhan M, Renn A, Shinn P, Shrimp JH, Viraktamath A, Wilson KM, Xu M, Zakharov AV, Zhu W, Zheng W, Simeonov A, Mathé EA, Lo DC, Hall MD, Shen M. Brimacombe KR, et al. Among authors: chen l, chen cz. bioRxiv [Preprint]. 2020 Jun 5:2020.06.04.135046. doi: 10.1101/2020.06.04.135046. bioRxiv. 2020. PMID: 32511420 Free PMC article. Preprint.
Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by Plasmodium falciparum Genotype.
Ansbro MR, Itkin Z, Chen L, Zahoranszky-Kohalmi G, Amaratunga C, Miotto O, Peryea T, Hobbs CV, Suon S, Sá JM, Dondorp AM, van der Pluijm RW, Wellems TE, Simeonov A, Eastman RT. Ansbro MR, et al. Among authors: chen l. ACS Pharmacol Transl Sci. 2020 Nov 2;3(6):1144-1157. doi: 10.1021/acsptsci.0c00110. eCollection 2020 Dec 11. ACS Pharmacol Transl Sci. 2020. PMID: 33344893 Free PMC article.
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