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Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. Nguyen TL, et al. Among authors: toribio ml. Mol Oncol. 2021 May;15(5):1412-1431. doi: 10.1002/1878-0261.12877. Epub 2021 Feb 13. Mol Oncol. 2021. PMID: 33314742 Free PMC article.
Regulation of the transcriptional program by DNA methylation during human αβ T-cell development.
Rodriguez RM, Suarez-Alvarez B, Mosén-Ansorena D, García-Peydró M, Fuentes P, García-León MJ, Gonzalez-Lahera A, Macias-Camara N, Toribio ML, Aransay AM, Lopez-Larrea C. Rodriguez RM, et al. Among authors: toribio ml. Nucleic Acids Res. 2015 Jan;43(2):760-74. doi: 10.1093/nar/gku1340. Epub 2014 Dec 24. Nucleic Acids Res. 2015. PMID: 25539926 Free PMC article.
The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.
García-Peydró M, Fuentes P, Mosquera M, García-León MJ, Alcain J, Rodríguez A, García de Miguel P, Menéndez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Muñoz-Calleja C, Sánchez-Madrid F, Toribio ML. García-Peydró M, et al. Among authors: toribio ml. J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21. J Clin Invest. 2018. PMID: 29781813 Free PMC article.
Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia.
Sánchez-Martínez D, Baroni ML, Gutierrez-Agüera F, Roca-Ho H, Blanch-Lombarte O, González-García S, Torrebadell M, Junca J, Ramírez-Orellana M, Velasco-Hernández T, Bueno C, Fuster JL, Prado JG, Calvo J, Uzan B, Cools J, Camos M, Pflumio F, Toribio ML, Menéndez P. Sánchez-Martínez D, et al. Among authors: toribio ml. Blood. 2019 May 23;133(21):2291-2304. doi: 10.1182/blood-2018-10-882944. Epub 2019 Feb 22. Blood. 2019. PMID: 30796021 Free PMC article.
Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells.
López-Guerra M, Xargay-Torrent S, Fuentes P, Roldán J, González-Farré B, Rosich L, Silkenstedt E, García-León MJ, Lee-Vergés E, Giménez N, Giró A, Aymerich M, Villamor N, Delgado J, López-Guillermo A, Puente XS, Campo E, Toribio ML, Colomer D. López-Guerra M, et al. Among authors: toribio ml. Oncogene. 2020 Feb;39(6):1185-1197. doi: 10.1038/s41388-019-1053-6. Epub 2019 Oct 15. Oncogene. 2020. PMID: 31616059 Free PMC article.
Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy.
Silkenstedt E, Arenas F, Colom-Sanmartí B, Xargay-Torrent S, Higashi M, Giró A, Rodriguez V, Fuentes P, Aulitzky WE, van der Kuip H, Beà S, Toribio ML, Campo E, López-Guerra M, Colomer D. Silkenstedt E, et al. Among authors: toribio ml. J Exp Clin Cancer Res. 2019 Nov 1;38(1):446. doi: 10.1186/s13046-019-1458-7. J Exp Clin Cancer Res. 2019. PMID: 31676012 Free PMC article.
118 results