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Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. Nguyen TL, et al. Among authors: soubeyran p. Mol Oncol. 2021 May;15(5):1412-1431. doi: 10.1002/1878-0261.12877. Epub 2021 Feb 13. Mol Oncol. 2021. PMID: 33314742 Free PMC article.
mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells.
Nguyen TL, Nokin MJ, Egorov M, Tomé M, Bodineau C, Di Primo C, Minder L, Wdzieczak-Bakala J, Garcia-Alvarez MC, Bignon J, Thoison O, Delpech B, Surpateanu G, Frapart YM, Peyrot F, Abbas K, Terés S, Evrard S, Khatib AM, Soubeyran P, Iorga BI, Durán RV, Collin P. Nguyen TL, et al. Among authors: soubeyran p. Cancer Res. 2018 Sep 15;78(18):5384-5397. doi: 10.1158/0008-5472.CAN-18-0232. Epub 2018 Jul 27. Cancer Res. 2018. PMID: 30054335
Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells.
Beauvarlet J, Bensadoun P, Darbo E, Labrunie G, Rousseau B, Richard E, Draskovic I, Londono-Vallejo A, Dupuy JW, Nath Das R, Guédin A, Robert G, Orange F, Croce S, Valesco V, Soubeyran P, Ryan KM, Mergny JL, Djavaheri-Mergny M. Beauvarlet J, et al. Among authors: soubeyran p. Nucleic Acids Res. 2019 Apr 8;47(6):2739-2756. doi: 10.1093/nar/gkz095. Nucleic Acids Res. 2019. PMID: 30759257 Free PMC article.
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Bodineau C, Tomé M, Courtois S, Costa ASH, Sciacovelli M, Rousseau B, Richard E, Vacher P, Parejo-Pérez C, Bessede E, Varon C, Soubeyran P, Frezza C, Murdoch PDS, Villar VH, Durán RV. Bodineau C, et al. Among authors: soubeyran p. Nat Commun. 2021 Aug 10;12(1):4814. doi: 10.1038/s41467-021-25079-4. Nat Commun. 2021. PMID: 34376668 Free PMC article.
Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells.
Beauvarlet J, Nath Das R, Alvarez-Valadez K, Martins I, Muller A, Darbo E, Richard E, Soubeyran P, Kroemer G, Guillon J, Mergny JL, Djavaheri-Mergny M. Beauvarlet J, et al. Among authors: soubeyran p. Cancers (Basel). 2020 Jun 18;12(6):1621. doi: 10.3390/cancers12061621. Cancers (Basel). 2020. PMID: 32570977 Free PMC article.
240 results