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Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations.
Kano M, Takanashi M, Oyama G, Yoritaka A, Hatano T, Shiba-Fukushima K, Nagai M, Nishiyama K, Hasegawa K, Inoshita T, Ishikawa KI, Akamatsu W, Imai Y, Bolognin S, Schwamborn JC, Hattori N. Kano M, et al. Among authors: akamatsu w. NPJ Parkinsons Dis. 2020 Nov 13;6(1):33. doi: 10.1038/s41531-020-00137-8. NPJ Parkinsons Dis. 2020. PMID: 33298969 Free PMC article.
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H. Imaizumi Y, et al. Among authors: akamatsu w. Mol Brain. 2012 Oct 6;5:35. doi: 10.1186/1756-6606-5-35. Mol Brain. 2012. PMID: 23039195 Free PMC article.
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.
Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H. Ohta E, et al. Among authors: akamatsu w. Hum Mol Genet. 2015 Sep 1;24(17):4879-900. doi: 10.1093/hmg/ddv212. Epub 2015 Jun 8. Hum Mol Genet. 2015. PMID: 26056228
Assessment of Mitophagy in iPS Cell-Derived Neurons.
Ishikawa KI, Yamaguchi A, Okano H, Akamatsu W. Ishikawa KI, et al. Among authors: akamatsu w. Methods Mol Biol. 2018;1759:59-67. doi: 10.1007/7651_2017_10. Methods Mol Biol. 2018. PMID: 28324490
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.
Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. Ren Q, et al. Among authors: akamatsu w. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5815-E5823. doi: 10.1073/pnas.1802179115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735655 Free PMC article.
101 results