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NQO1 protects obese mice through improvements in glucose and lipid metabolism.
Di Francesco A, Choi Y, Bernier M, Zhang Y, Diaz-Ruiz A, Aon MA, Kalafut K, Ehrlich MR, Murt K, Ali A, Pearson KJ, Levan S, Preston JD, Martin-Montalvo A, Martindale JL, Abdelmohsen K, Michel CR, Willmes DM, Henke C, Navas P, Villalba JM, Siegel D, Gorospe M, Fritz K, Biswal S, Ross D, de Cabo R. Di Francesco A, et al. Among authors: pearson kj. NPJ Aging Mech Dis. 2020 Nov 19;6(1):13. doi: 10.1038/s41514-020-00051-6. NPJ Aging Mech Dis. 2020. PMID: 33298924 Free PMC article.
Cytochrome b5 reductase and the control of lipid metabolism and healthspan.
Martin-Montalvo A, Sun Y, Diaz-Ruiz A, Ali A, Gutierrez V, Palacios HH, Curtis J, Siendones E, Ariza J, Abulwerdi GA, Sun X, Wang AX, Pearson KJ, Fishbein KW, Spencer RG, Wang M, Han X, Scheibye-Knudsen M, Baur JA, Shertzer HG, Navas P, Villalba JM, Zou S, Bernier M, de Cabo R. Martin-Montalvo A, et al. Among authors: pearson kj. NPJ Aging Mech Dis. 2016 May 12;2:16006. doi: 10.1038/npjamd.2016.6. eCollection 2016. NPJ Aging Mech Dis. 2016. PMID: 28721264 Free PMC article.
Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.
Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon MA, Fishbein KW, Pearson KJ, Villalba JM, Navas P, Bernier M, de Cabo R. Diaz-Ruiz A, et al. Among authors: pearson kj. Aging Cell. 2018 Aug;17(4):e12767. doi: 10.1111/acel.12767. Epub 2018 Apr 28. Aging Cell. 2018. PMID: 29706024 Free PMC article.
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Among authors: pearson kj. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.
Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.
Bernier M, Wahl D, Ali A, Allard J, Faulkner S, Wnorowski A, Sanghvi M, Moaddel R, Alfaras I, Mattison JA, Tarantini S, Tucsek Z, Ungvari Z, Csiszar A, Pearson KJ, de Cabo R. Bernier M, et al. Among authors: pearson kj. Aging (Albany NY). 2016 May;8(5):899-916. doi: 10.18632/aging.100942. Aging (Albany NY). 2016. PMID: 27070252 Free PMC article.
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.
Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R. Jimenez-Gomez Y, et al. Among authors: pearson kj. Cell Metab. 2013 Oct 1;18(4):533-45. doi: 10.1016/j.cmet.2013.09.004. Cell Metab. 2013. PMID: 24093677 Free PMC article.
Chronic Exposure to Cadmium Induces Differential Methylation in Mice Spermatozoa.
Saintilnord WN, Tenlep SYN, Preston JD, Duregon E, DeRouchey JE, Unrine JM, de Cabo R, Pearson KJ, Fondufe-Mittendorf YN. Saintilnord WN, et al. Among authors: pearson kj. Toxicol Sci. 2021 Apr 12;180(2):262-276. doi: 10.1093/toxsci/kfab002. Toxicol Sci. 2021. PMID: 33483743 Free PMC article.
81 results