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A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids.
PLoS Pathog. 2020 Dec 8;16(12):e1009119. doi: 10.1371/journal.ppat.1009119. eCollection 2020 Dec.
PLoS Pathog. 2020.
PMID: 33290418
Free PMC article.
Autophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and Mice.
Nagy TA, Quintana JLJ, Reens AL, Crooks AL, Detweiler CS.
Nagy TA, et al. Among authors: quintana jlj.
Antimicrob Agents Chemother. 2019 Sep 9;63(12):e01536-19. doi: 10.1128/AAC.01536-19. Epub 2019 Oct 7.
Antimicrob Agents Chemother. 2019.
PMID: 31591121
Free PMC article.
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Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice.
Nagy TA, Crooks AL, Quintana JLJ, Detweiler CS.
Nagy TA, et al. Among authors: quintana jlj.
ACS Infect Dis. 2020 May 8;6(5):1238-1249. doi: 10.1021/acsinfecdis.0c00023. Epub 2020 Apr 29.
ACS Infect Dis. 2020.
PMID: 32272013
Free PMC article.
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Staphylococcal Bacterial Persister Cells, Biofilms, and Intracellular Infection Are Disrupted by JD1, a Membrane-Damaging Small Molecule.
Dombach JL, Quintana JLJ, Detweiler CS.
Dombach JL, et al. Among authors: quintana jlj.
mBio. 2021 Oct 26;12(5):e0180121. doi: 10.1128/mBio.01801-21. Epub 2021 Oct 12.
mBio. 2021.
PMID: 34634935
Free PMC article.
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A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice.
Dombach JL, Quintana JL, Allgood SC, Nagy TA, Gustafson DL, Detweiler CS.
Dombach JL, et al.
PLoS Pathog. 2022 Jun 10;18(6):e1010606. doi: 10.1371/journal.ppat.1010606. eCollection 2022 Jun.
PLoS Pathog. 2022.
PMID: 35687608
Free PMC article.
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Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes.
Villanueva JA, Crooks AL, Nagy TA, Quintana JLJ, Dalebroux ZD, Detweiler CS.
Villanueva JA, et al. Among authors: quintana jlj.
mBio. 2022 Oct 26;13(5):e0179022. doi: 10.1128/mbio.01790-22. Epub 2022 Sep 22.
mBio. 2022.
PMID: 36135367
Free PMC article.
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Inhibition of multiple staphylococcal growth states by a small molecule that disrupts membrane fluidity and voltage.
Dombach JL, Christensen GL, Allgood SC, Quintana JLJ, Detweiler CS.
Dombach JL, et al. Among authors: quintana jlj.
mSphere. 2024 Mar 26;9(3):e0077223. doi: 10.1128/msphere.00772-23. Epub 2024 Mar 6.
mSphere. 2024.
PMID: 38445864
Free PMC article.
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