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Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease.
Wilson RB, Zhang R, Chen YJ, Peters KM, Sawyez CG, Sutherland BG, Patel K, Kennelly JP, Leonard KA, Jacobs RL, Wang R, Borradaile NM. Wilson RB, et al. Among authors: kennelly jp. Int J Mol Sci. 2020 Dec 1;21(23):9156. doi: 10.3390/ijms21239156. Int J Mol Sci. 2020. PMID: 33271781 Free PMC article.
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Jacobs RL, Jiang H, Kennelly JP, Orlicky DJ, Allen RH, Stabler SP, Maclean KN. Jacobs RL, et al. Among authors: kennelly jp. Mol Genet Metab. 2017 Apr;120(4):325-336. doi: 10.1016/j.ymgme.2017.02.010. Epub 2017 Mar 2. Mol Genet Metab. 2017. PMID: 28291718
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Wilson RB, Chen YJ, Sutherland BG, Sawyez CG, Zhang R, Woolnough T, Hetherington AM, Peters KM, Patel K, Kennelly JP, Leonard KA, Schuurman M, Jacobs RL, Wang R, Borradaile NM. Wilson RB, et al. Among authors: kennelly jp. Pharmacol Res. 2020 Nov;161:105208. doi: 10.1016/j.phrs.2020.105208. Epub 2020 Sep 22. Pharmacol Res. 2020. PMID: 32977024 Free article.
De novo phosphatidylcholine synthesis in the small intestinal epithelium is required for normal dietary lipid handling and maintenance of the mucosal barrier.
Carlin S, Kennelly JP, Fedoruk H, Quiroga A, Leonard KA, Nelson R, Thiesen A, Buteau J, Lehner R, Jacobs R. Carlin S, et al. Among authors: kennelly jp. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Apr;1867(4):159109. doi: 10.1016/j.bbalip.2021.159109. Epub 2022 Jan 7. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35007755
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis.
Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Xiao X, et al. Among authors: kennelly jp. Nat Metab. 2023 Jan;5(1):165-181. doi: 10.1038/s42255-022-00722-6. Epub 2023 Jan 16. Nat Metab. 2023. PMID: 36646756 Free PMC article.
22 results