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A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy.
Cohen JE, Purcell BP, MacArthur JW Jr, Mu A, Shudo Y, Patel JB, Brusalis CM, Trubelja A, Fairman AS, Edwards BB, Davis MS, Hung G, Hiesinger W, Atluri P, Margulies KB, Burdick JA, Woo YJ. Cohen JE, et al. Circ Heart Fail. 2014 Jul;7(4):619-26. doi: 10.1161/CIRCHEARTFAILURE.113.001273. Epub 2014 Jun 5. Circ Heart Fail. 2014. PMID: 24902740 Free PMC article.
Sustained release of engineered stromal cell-derived factor 1-α from injectable hydrogels effectively recruits endothelial progenitor cells and preserves ventricular function after myocardial infarction.
MacArthur JW Jr, Purcell BP, Shudo Y, Cohen JE, Fairman A, Trubelja A, Patel J, Hsiao P, Yang E, Lloyd K, Hiesinger W, Atluri P, Burdick JA, Woo YJ. MacArthur JW Jr, et al. Among authors: cohen je. Circulation. 2013 Sep 10;128(11 Suppl 1):S79-86. doi: 10.1161/CIRCULATIONAHA.112.000343. Circulation. 2013. PMID: 24030424 Free PMC article.
Preclinical evaluation of the engineered stem cell chemokine stromal cell-derived factor 1α analog in a translational ovine myocardial infarction model.
Macarthur JW Jr, Cohen JE, McGarvey JR, Shudo Y, Patel JB, Trubelja A, Fairman AS, Edwards BB, Hung G, Hiesinger W, Goldstone AB, Atluri P, Wilensky RL, Pilla JJ, Gorman JH 3rd, Gorman RC, Woo YJ. Macarthur JW Jr, et al. Among authors: cohen je. Circ Res. 2014 Feb 14;114(4):650-9. doi: 10.1161/CIRCRESAHA.114.302884. Epub 2013 Dec 23. Circ Res. 2014. PMID: 24366171 Free PMC article.
Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function.
Atluri P, Miller JS, Emery RJ, Hung G, Trubelja A, Cohen JE, Lloyd K, Han J, Gaffey AC, MacArthur JW, Chen CS, Woo YJ. Atluri P, et al. Among authors: cohen je. J Thorac Cardiovasc Surg. 2014 Sep;148(3):1090-7; discussion 1097-8. doi: 10.1016/j.jtcvs.2014.06.038. Epub 2014 Jun 28. J Thorac Cardiovasc Surg. 2014. PMID: 25129603 Free PMC article.
A Tissue-Engineered Chondrocyte Cell Sheet Induces Extracellular Matrix Modification to Enhance Ventricular Biomechanics and Attenuate Myocardial Stiffness in Ischemic Cardiomyopathy.
Shudo Y, Cohen JE, MacArthur JW, Goldstone AB, Otsuru S, Trubelja A, Patel J, Edwards BB, Hung G, Fairman AS, Brusalis C, Hiesinger W, Atluri P, Hiraoka A, Miyagawa S, Sawa Y, Woo YJ. Shudo Y, et al. Among authors: cohen je. Tissue Eng Part A. 2015 Oct;21(19-20):2515-25. doi: 10.1089/ten.TEA.2014.0155. Epub 2015 Sep 18. Tissue Eng Part A. 2015. PMID: 26154752 Free PMC article.
774 results