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Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells.
Souza BM, Preisser TM, Pereira VB, Zurita-Turk M, de Castro CP, da Cunha VP, de Oliveira RP, Gomes-Santos AC, de Faria AM, Machado DC, Chatel JM, Azevedo VA, Langella P, Miyoshi A. Souza BM, et al. Microb Cell Fact. 2016 Aug 30;15(1):150. doi: 10.1186/s12934-016-0548-x. Microb Cell Fact. 2016. PMID: 27576902 Free PMC article.