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Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease.
Mirzaei N, Mota BC, Birch AM, Davis N, Romero-Molina C, Katsouri L, Palmer EOC, Golbano A, Riggall LJ, Nagy I, Tyacke R, Nutt DJ, Sastre M. Mirzaei N, et al. Among authors: sastre m. Br J Pharmacol. 2021 Feb;178(3):654-671. doi: 10.1111/bph.15312. Epub 2020 Dec 27. Br J Pharmacol. 2021. PMID: 33140839 Free article.
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
Torres M, Price SL, Fiol-Deroque MA, Marcilla-Etxenike A, Ahyayauch H, Barceló-Coblijn G, Terés S, Katsouri L, Ordinas M, López DJ, Ibarguren M, Goñi FM, Busquets X, Vitorica J, Sastre M, Escribá PV. Torres M, et al. Among authors: sastre m. Biochim Biophys Acta. 2014 Jun;1838(6):1680-92. doi: 10.1016/j.bbamem.2013.12.016. Epub 2013 Dec 27. Biochim Biophys Acta. 2014. PMID: 24374316 Free article.
Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.
Parr C, Mirzaei N, Christian M, Sastre M. Parr C, et al. Among authors: sastre m. FASEB J. 2015 Feb;29(2):623-35. doi: 10.1096/fj.14-253211. Epub 2014 Nov 10. FASEB J. 2015. PMID: 25384422
In conclusion, Wnt/beta-catenin stimulation may repress BACE1 transcription via binding of TCF4 to BACE1 gene, and therefore, activation of the Wnt pathway may hold the key to new treatments of Alzheimer disease.-Parr, C., Mirzaei, N., Christian, M., and Sastre, …
In conclusion, Wnt/beta-catenin stimulation may repress BACE1 transcription via binding of TCF4 to BACE1 gene, and therefore, activation of …
168 results