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Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice.
Gioscia-Ryan RA, Clayton ZS, Zigler MC, Richey JJ, Cuevas LM, Rossman MJ, Battson ML, Ziemba BP, Hutton DA, VanDongen NS, Seals DR. Gioscia-Ryan RA, et al. Among authors: vandongen ns. J Physiol. 2021 Feb;599(3):911-925. doi: 10.1113/JP280607. Epub 2020 Oct 28. J Physiol. 2021. PMID: 33103241 Free PMC article.
Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Brunt VE, et al. Among authors: vandongen ns. Hypertension. 2021 Aug;78(2):499-511. doi: 10.1161/HYPERTENSIONAHA.120.16895. Epub 2021 May 10. Hypertension. 2021. PMID: 33966451 Free PMC article.
Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging.
Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Clayton ZS, et al. Among authors: vandongen ns. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H185-H196. doi: 10.1152/ajpheart.00118.2021. Epub 2021 Jun 11. Am J Physiol Heart Circ Physiol. 2021. PMID: 34114892 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35554151
[No title available]
[No authors listed] [No authors listed] PMID: 35560440
Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice.
Brunt VE, Greenberg NT, Sapinsley ZJ, Casso AG, Richey JJ, VanDongen NS, Gioscia-Ryan RA, Ziemba BP, Neilson AP, Davy KP, Seals DR. Brunt VE, et al. Among authors: vandongen ns. J Appl Physiol (1985). 2022 Oct 1;133(4):798-813. doi: 10.1152/japplphysiol.00350.2022. Epub 2022 Aug 11. J Appl Physiol (1985). 2022. PMID: 35952350 Free PMC article.
Female C57BL/6N mice are a viable model of aortic aging in women.
Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Longtine AG, et al. Among authors: vandongen ns. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H893-H904. doi: 10.1152/ajpheart.00120.2023. Epub 2023 Apr 28. Am J Physiol Heart Circ Physiol. 2023. PMID: 37115626 Free PMC article.
13 results