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Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice.
J Physiol. 2021 Feb;599(3):911-925. doi: 10.1113/JP280607. Epub 2020 Oct 28.
J Physiol. 2021.
PMID: 33103241
Free PMC article.
Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Brunt VE, Gioscia-Ryan RA, Richey JJ, Zigler MC, Cuevas LM, Gonzalez A, Vázquez-Baeza Y, Battson ML, Smithson AT, Gilley AD, Ackermann G, Neilson AP, Weir T, Davy KP, Knight R, Seals DR.
Brunt VE, et al. Among authors: richey jj.
J Physiol. 2019 May;597(9):2361-2378. doi: 10.1113/JP277336. Epub 2019 Feb 27.
J Physiol. 2019.
PMID: 30714619
Free PMC article.
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Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
Brunt VE, Gioscia-Ryan RA, Casso AG, VanDongen NS, Ziemba BP, Sapinsley ZJ, Richey JJ, Zigler MC, Neilson AP, Davy KP, Seals DR.
Brunt VE, et al. Among authors: richey jj.
Hypertension. 2020 Jul;76(1):101-112. doi: 10.1161/HYPERTENSIONAHA.120.14759. Epub 2020 Jun 10.
Hypertension. 2020.
PMID: 32520619
Free PMC article.
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Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice.
Brunt VE, Greenberg NT, Sapinsley ZJ, Casso AG, Richey JJ, VanDongen NS, Gioscia-Ryan RA, Ziemba BP, Neilson AP, Davy KP, Seals DR.
Brunt VE, et al. Among authors: richey jj.
J Appl Physiol (1985). 2022 Oct 1;133(4):798-813. doi: 10.1152/japplphysiol.00350.2022. Epub 2022 Aug 11.
J Appl Physiol (1985). 2022.
PMID: 35952350
Free PMC article.
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Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice.
Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR.
Ballak DB, et al. Among authors: richey jj.
Aging Cell. 2020 Jan;19(1):e13074. doi: 10.1111/acel.13074. Epub 2019 Nov 21.
Aging Cell. 2020.
PMID: 31755162
Free PMC article.
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Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR.
Brunt VE, et al. Among authors: richey jj.
Hypertension. 2021 Aug;78(2):499-511. doi: 10.1161/HYPERTENSIONAHA.120.16895. Epub 2021 May 10.
Hypertension. 2021.
PMID: 33966451
Free PMC article.
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Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults.
Martens CR, Rossman MJ, Mazzo MR, Jankowski LR, Nagy EE, Denman BA, Richey JJ, Johnson SA, Ziemba BP, Wang Y, Peterson CM, Chonchol M, Seals DR.
Martens CR, et al. Among authors: richey jj.
Geroscience. 2020 Apr;42(2):667-686. doi: 10.1007/s11357-020-00156-6. Epub 2020 Jan 23.
Geroscience. 2020.
PMID: 31975053
Free PMC article.
Clinical Trial.
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