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Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation.
Boff L, Schreiber A, da Rocha Matos A, Del Sarto J, Brunotte L, Munkert J, Melo Ottoni F, Silva Ramos G, Kreis W, Castro Braga F, José Alves R, Maia de Pádua R, Maria Oliveira Simões C, Ludwig S. Boff L, et al. Among authors: kreis w. Molecules. 2020 Oct 21;25(20):4853. doi: 10.3390/molecules25204853. Molecules. 2020. PMID: 33096707 Free PMC article.
A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines.
Nolte E, Wach S, Silva IT, Lukat S, Ekici AB, Munkert J, Müller-Uri F, Kreis W, Oliveira Simões CM, Vera J, Wullich B, Taubert H, Lai X. Nolte E, et al. Among authors: kreis w. Oncotarget. 2017 Feb 14;8(7):11676-11691. doi: 10.18632/oncotarget.14644. Oncotarget. 2017. PMID: 28099931 Free PMC article.
Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.
Munkert J, Santiago Franco M, Nolte E, Thaís Silva I, Oliveira Castilho R, Melo Ottoni F, Schneider NFZ, Oliveira MC, Taubert H, Bauer W, Andrade SF, Alves RJ, Simões CMO, Braga FC, Kreis W, de Pádua RM. Munkert J, et al. Among authors: kreis w. Planta Med. 2017 Aug;83(12-13):1035-1043. doi: 10.1055/s-0043-109557. Epub 2017 May 9. Planta Med. 2017. PMID: 28486743
Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase.
Schneider NFZ, Persich L, Rocha SC, Ramos ACP, Cortes VF, Silva IT, Munkert J, Pádua RM, Kreis W, Taranto AG, Barbosa LA, Braga FC, Simões CMO. Schneider NFZ, et al. Among authors: kreis w. Biomed Pharmacother. 2018 Jan;97:684-696. doi: 10.1016/j.biopha.2017.10.128. Epub 2017 Nov 6. Biomed Pharmacother. 2018. PMID: 29101813
184 results