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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Kaptein SJF, Jacobs S, Langendries L, Seldeslachts L, Ter Horst S, Liesenborghs L, Hens B, Vergote V, Heylen E, Barthelemy K, Maas E, De Keyzer C, Bervoets L, Rymenants J, Van Buyten T, Zhang X, Abdelnabi R, Pang J, Williams R, Thibaut HJ, Dallmeier K, Boudewijns R, Wouters J, Augustijns P, Verougstraete N, Cawthorne C, Breuer J, Solas C, Weynand B, Annaert P, Spriet I, Vande Velde G, Neyts J, Rocha-Pereira J, Delang L. Kaptein SJF, et al. Among authors: neyts j. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26955-26965. doi: 10.1073/pnas.2014441117. Epub 2020 Oct 9. Proc Natl Acad Sci U S A. 2020. PMID: 33037151 Free PMC article.
Growth kinetics of SARS-coronavirus in Vero E6 cells.
Keyaerts E, Vijgen L, Maes P, Neyts J, Van Ranst M. Keyaerts E, et al. Among authors: neyts j. Biochem Biophys Res Commun. 2005 Apr 15;329(3):1147-51. doi: 10.1016/j.bbrc.2005.02.085. Biochem Biophys Res Commun. 2005. PMID: 15752773 Free PMC article.
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors.
Coelmont L, Kaptein S, Paeshuyse J, Vliegen I, Dumont JM, Vuagniaux G, Neyts J. Coelmont L, et al. Among authors: neyts j. Antimicrob Agents Chemother. 2009 Mar;53(3):967-76. doi: 10.1128/AAC.00939-08. Epub 2008 Dec 22. Antimicrob Agents Chemother. 2009. PMID: 19104013 Free PMC article.
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.
De Palma AM, Thibaut HJ, van der Linden L, Lanke K, Heggermont W, Ireland S, Andrews R, Arimilli M, Al-Tel TH, De Clercq E, van Kuppeveld F, Neyts J. De Palma AM, et al. Among authors: neyts j. Antimicrob Agents Chemother. 2009 May;53(5):1850-7. doi: 10.1128/AAC.00934-08. Epub 2009 Feb 23. Antimicrob Agents Chemother. 2009. PMID: 19237651 Free PMC article.
9-Arylpurines as a novel class of enterovirus inhibitors.
Aguado L, Thibaut HJ, Priego EM, Jimeno ML, Camarasa MJ, Neyts J, Pérez-Pérez MJ. Aguado L, et al. Among authors: neyts j. J Med Chem. 2010 Jan 14;53(1):316-24. doi: 10.1021/jm901240p. J Med Chem. 2010. PMID: 19924996
662 results