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FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer.
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OM, Martineau Y, Pyronnet S, Bousquet C, Jean C. Zaghdoudi S, et al. Among authors: tomasini r. EMBO Mol Med. 2020 Nov 6;12(11):e12010. doi: 10.15252/emmm.202012010. Epub 2020 Oct 7. EMBO Mol Med. 2020. PMID: 33025708 Free PMC article.
Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling.
Secq V, Leca J, Bressy C, Guillaumond F, Skrobuk P, Nigri J, Lac S, Lavaut MN, Bui TT, Thakur AK, Callizot N, Steinschneider R, Berthezene P, Dusetti N, Ouaissi M, Moutardier V, Calvo E, Bousquet C, Garcia S, Bidaut G, Vasseur S, Iovanna JL, Tomasini R. Secq V, et al. Among authors: tomasini r. Cell Death Dis. 2015 Jan 15;6(1):e1592. doi: 10.1038/cddis.2014.557. Cell Death Dis. 2015. PMID: 25590802 Free PMC article.
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance.
Duluc C, Moatassim-Billah S, Chalabi-Dchar M, Perraud A, Samain R, Breibach F, Gayral M, Cordelier P, Delisle MB, Bousquet-Dubouch MP, Tomasini R, Schmid H, Mathonnet M, Pyronnet S, Martineau Y, Bousquet C. Duluc C, et al. Among authors: tomasini r. EMBO Mol Med. 2015 Jun;7(6):735-53. doi: 10.15252/emmm.201404346. EMBO Mol Med. 2015. PMID: 25834145 Free PMC article.
Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.
Leca J, Martinez S, Lac S, Nigri J, Secq V, Rubis M, Bressy C, Sergé A, Lavaut MN, Dusetti N, Loncle C, Roques J, Pietrasz D, Bousquet C, Garcia S, Granjeaud S, Ouaissi M, Bachet JB, Brun C, Iovanna JL, Zimmermann P, Vasseur S, Tomasini R. Leca J, et al. Among authors: tomasini r. J Clin Invest. 2016 Nov 1;126(11):4140-4156. doi: 10.1172/JCI87734. Epub 2016 Oct 4. J Clin Invest. 2016. PMID: 27701147 Free PMC article.
PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker.
Nigri J, Gironella M, Bressy C, Vila-Navarro E, Roques J, Lac S, Bontemps C, Kozaczyk C, Cros J, Pietrasz D, Maréchal R, Van Laethem JL, Iovanna J, Bachet JB, Folch-Puy E, Tomasini R. Nigri J, et al. Among authors: tomasini r. Cell Mol Life Sci. 2017 Nov;74(22):4231-4243. doi: 10.1007/s00018-017-2579-9. Epub 2017 Jun 27. Cell Mol Life Sci. 2017. PMID: 28656348 Free PMC article.
Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer.
Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, Zhang X, Zhao Y, Kim IS, Chanal M, Curto R, Hervieu V, de La Fouchardière C, Novelli F, Milani P, Tomasini R, Bousquet C, Bertolino P, Hennino A. Goehrig D, et al. Among authors: tomasini r. Gut. 2019 Apr;68(4):693-707. doi: 10.1136/gutjnl-2018-317570. Epub 2018 Nov 10. Gut. 2019. PMID: 30415234 Free PMC article.
Schwann cells support oncogenic potential of pancreatic cancer cells through TGFβ signaling.
Roger E, Martel S, Bertrand-Chapel A, Depollier A, Chuvin N, Pommier RM, Yacoub K, Caligaris C, Cardot-Ruffino V, Chauvet V, Aires S, Mohkam K, Mabrut JY, Adham M, Fenouil T, Hervieu V, Broutier L, Castets M, Neuzillet C, Cassier PA, Tomasini R, Sentis S, Bartholin L. Roger E, et al. Among authors: tomasini r. Cell Death Dis. 2019 Nov 25;10(12):886. doi: 10.1038/s41419-019-2116-x. Cell Death Dis. 2019. PMID: 31767842 Free PMC article.
Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages.
Samain R, Brunel A, Douché T, Fanjul M, Cassant-Sourdy S, Rochotte J, Cros J, Neuzillet C, Raffenne J, Duluc C, Perraud A, Nigri J, Gigoux V, Bieche I, Ponzo M, Carpentier G, Cascone I, Tomasini R, Schmid HA, Mathonnet M, Nicolle R, Bousquet MP, Martineau Y, Pyronnet S, Jean C, Bousquet C. Samain R, et al. Among authors: tomasini r. Cell Mol Gastroenterol Hepatol. 2021;11(5):1405-1436. doi: 10.1016/j.jcmgh.2021.01.008. Epub 2021 Jan 20. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33482394 Free PMC article.
SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer.
Rapetti-Mauss R, Nigri J, Berenguier C, Finetti P, Tubiana SS, Labrum B, Allegrini B, Pellissier B, Efthymiou G, Hussain Z, Bousquet C, Dusetti N, Bertucci F, Guizouarn H, Melnyk P, Borgese F, Tomasini R, Soriani O. Rapetti-Mauss R, et al. Among authors: tomasini r. Gut. 2023 Apr;72(4):722-735. doi: 10.1136/gutjnl-2021-326610. Epub 2022 Sep 1. Gut. 2023. PMID: 36882214
75 results