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The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer.
Front Pharmacol. 2020 Sep 3;11:1297. doi: 10.3389/fphar.2020.01297. eCollection 2020.
Front Pharmacol. 2020.
PMID: 33013366
Free PMC article.
Review.
Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.
Maucher IV, Rühl M, Kretschmer SB, Hofmann B, Kühn B, Fettel J, Vogel A, Flügel KT, Manolikakes G, Hellmuth N, Häfner AK, Golghalyani V, Ball AK, Piesche M, Matrone C, Geisslinger G, Parnham MJ, Karas M, Steinhilber D, Roos J, Maier TJ.
Maucher IV, et al. Among authors: hellmuth n.
Biochem Pharmacol. 2017 Feb 1;125:55-74. doi: 10.1016/j.bcp.2016.11.004. Epub 2016 Nov 4.
Biochem Pharmacol. 2017.
PMID: 27823964
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Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Roos J, Peters M, Maucher IV, Kühn B, Fettel J, Hellmuth N, Brat C, Sommer B, Urbschat A, Piesche M, Vogel A, Proschak E, Blöcher R, Buscató E, Häfner AK, Matrone C, Werz O, Heidler J, Wittig I, Angioni C, Geisslinger G, Parnham MJ, Zacharowski K, Steinhilber D, Maier TJ.
Roos J, et al. Among authors: hellmuth n.
Antioxid Redox Signal. 2018 May 10;28(14):1265-1285. doi: 10.1089/ars.2017.7155. Epub 2017 Sep 8.
Antioxid Redox Signal. 2018.
PMID: 28699354
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Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells.
Kühn B, Brat C, Fettel J, Hellmuth N, Maucher IV, Bulut U, Hock KJ, Grimmer J, Manolikakes G, Rühl M, Kühn A, Zacharowski K, Matrone C, Urbschat A, Roos J, Steinhilber D, Maier TJ.
Kühn B, et al. Among authors: hellmuth n.
Biochem Pharmacol. 2018 Sep;155:48-60. doi: 10.1016/j.bcp.2018.06.014. Epub 2018 Jun 15.
Biochem Pharmacol. 2018.
PMID: 29909078
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Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids.
Hellmuth N, Brat C, Awad O, George S, Kahnt A, Bauer T, Huynh Phuoc HP, Steinhilber D, Angioni C, Hassan M, Hock KJ, Manolikakes G, Zacharowski K, Roos J, Maier TJ.
Hellmuth N, et al.
Front Pharmacol. 2021 Nov 18;12:715076. doi: 10.3389/fphar.2021.715076. eCollection 2021.
Front Pharmacol. 2021.
PMID: 34867322
Free PMC article.
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Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome.
Brat C, Huynh Phuoc HP, Awad O, Parmar BS, Hellmuth N, Heinicke U, Amr S, Grimmer J, Sürün D, Husnjak K, Carlsson M, Fahrer J, Bauer T, Krieg SC, Manolikakes G, Zacharowski K, Steinhilber D, Münch C, Maier TJ, Roos J.
Brat C, et al. Among authors: hellmuth n.
Cell Chem Biol. 2023 Oct 19;30(10):1277-1294.e12. doi: 10.1016/j.chembiol.2023.06.017. Epub 2023 Jul 19.
Cell Chem Biol. 2023.
PMID: 37473760
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A multidisciplinary approach to ritual enema scenes on ancient Maya pottery.
de Smet PA, Hellmuth NM.
de Smet PA, et al. Among authors: hellmuth nm.
J Ethnopharmacol. 1986 Jun;16(2-3):213-62. doi: 10.1016/0378-8741(86)90091-7.
J Ethnopharmacol. 1986.
PMID: 3528674
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