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BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis.
Tiwari S, Dutt TS, Chen B, Chen M, Kim J, Dai AZ, Lukose R, Shanley C, Fox A, Karger BR, Porcelli SA, Chan J, Podell BK, Obregon-Henao A, Orme IM, Jacobs WR Jr, Henao-Tamayo M. Tiwari S, et al. Vaccine. 2020 Oct 21;38(45):7156-7165. doi: 10.1016/j.vaccine.2020.08.004. Epub 2020 Sep 23. Vaccine. 2020. PMID: 32978002 Free PMC article.
XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability.
Ordway D, Higgins DM, Sanchez-Campillo J, Spencer JS, Henao-Tamayo M, Harton M, Orme IM, Gonzalez Juarrero M. Ordway D, et al. J Leukoc Biol. 2007 Nov;82(5):1221-9. doi: 10.1189/jlb.0607426. Epub 2007 Aug 15. J Leukoc Biol. 2007. PMID: 17699612
Animal model of Mycobacterium abscessus lung infection.
Ordway D, Henao-Tamayo M, Smith E, Shanley C, Harton M, Troudt J, Bai X, Basaraba RJ, Orme IM, Chan ED. Ordway D, et al. J Leukoc Biol. 2008 Jun;83(6):1502-11. doi: 10.1189/jlb.1007696. Epub 2008 Feb 29. J Leukoc Biol. 2008. PMID: 18310351
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