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Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase.
Mazzio E, Badisa R, Mack N, Cassim S, Zdralevic M, Pouyssegur J, Soliman KFA. Mazzio E, et al. Among authors: pouyssegur j. Cancer Genomics Proteomics. 2020 Sep-Oct;17(5):469-497. doi: 10.21873/cgp.20205. Cancer Genomics Proteomics. 2020. PMID: 32859627 Free PMC article.
Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia.
de Padua MC, Delodi G, Vučetić M, Durivault J, Vial V, Bayer P, Noleto GR, Mazure NM, Ždralević M, Pouysségur J. de Padua MC, et al. Among authors: pouyssegur j. Oncotarget. 2017 Sep 18;8(50):87623-87637. doi: 10.18632/oncotarget.21007. eCollection 2017 Oct 20. Oncotarget. 2017. PMID: 29152106 Free PMC article.
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.
Ždralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouysségur J, Kreutz M. Ždralević M, et al. Among authors: pouyssegur j. J Biol Chem. 2018 Oct 12;293(41):15947-15961. doi: 10.1074/jbc.RA118.004180. Epub 2018 Aug 29. J Biol Chem. 2018. PMID: 30158244 Free PMC article.
447 results