Roldan A - Search Results

1

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination.

Veit G, Roldan A, Hancock MA, Da Fonte DF, Xu H, Hussein M, Frenkiel S, Matouk E, Velkov T, Lukacs GL. Veit G, et al. Among authors: roldan a. JCI Insight. 2020 Sep 17;5(18):e139983. doi: 10.1172/jci.insight.139983. JCI Insight. 2020. PMID: 32853178 Free PMC article.

2

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.

Rabeh WM, Bossard F, Xu H, Okiyoneda T, Bagdany M, Mulvihill CM, Du K, di Bernardo S, Liu Y, Konermann L, Roldan A, Lukacs GL. Rabeh WM, et al. Among authors: roldan a. Cell. 2012 Jan 20;148(1-2):150-63. doi: 10.1016/j.cell.2011.11.024. Cell. 2012. PMID: 22265408 Free PMC article.

3

Mechanism-based corrector combination restores ΔF508-CFTR folding and function.

Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Okiyoneda T, et al. Among authors: roldan a. Nat Chem Biol. 2013 Jul;9(7):444-54. doi: 10.1038/nchembio.1253. Epub 2013 May 12. Nat Chem Biol. 2013. PMID: 23666117 Free PMC article.

4

Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.

Odolczyk N, Fritsch J, Norez C, Servel N, da Cunha MF, Bitam S, Kupniewska A, Wiszniewski L, Colas J, Tarnowski K, Tondelier D, Roldan A, Saussereau EL, Melin-Heschel P, Wieczorek G, Lukacs GL, Dadlez M, Faure G, Herrmann H, Ollero M, Becq F, Zielenkiewicz P, Edelman A. Odolczyk N, et al. Among authors: roldan a. EMBO Mol Med. 2013 Oct;5(10):1484-501. doi: 10.1002/emmm.201302699. Epub 2013 Aug 27. EMBO Mol Med. 2013. PMID: 23982976 Free PMC article.

5

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. Phuan PW, et al. Among authors: roldan a. Mol Pharmacol. 2014 Jul;86(1):42-51. doi: 10.1124/mol.114.092478. Epub 2014 Apr 15. Mol Pharmacol. 2014. PMID: 24737137 Free PMC article.

6

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration.

Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A. Kharitidi D, et al. Among authors: roldan a. Cell Rep. 2015 Oct 20;13(3):599-609. doi: 10.1016/j.celrep.2015.09.024. Epub 2015 Oct 8. Cell Rep. 2015. PMID: 26456826 Free article.

7

Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation.

Gong X, Ahner A, Roldan A, Lukacs GL, Thibodeau PH, Frizzell RA. Gong X, et al. Among authors: roldan a. J Biol Chem. 2016 Jan 22;291(4):2004-2017. doi: 10.1074/jbc.M115.685628. Epub 2015 Dec 1. J Biol Chem. 2016. PMID: 26627832 Free PMC article.

8

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.

Gakhal AK, Jensen TJ, Bozoky Z, Roldan A, Lukacs GL, Forman-Kay J, Riordan JR, Sidhu SS. Gakhal AK, et al. Among authors: roldan a. MAbs. 2016 Aug-Sep;8(6):1167-76. doi: 10.1080/19420862.2016.1186320. Epub 2016 May 16. MAbs. 2016. PMID: 27185291 Free PMC article.

9

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis.

Faure G, Bakouh N, Lourdel S, Odolczyk N, Premchandar A, Servel N, Hatton A, Ostrowski MK, Xu H, Saul FA, Moquereau C, Bitam S, Pranke I, Planelles G, Teulon J, Herrmann H, Roldan A, Zielenkiewicz P, Dadlez M, Lukacs GL, Sermet-Gaudelus I, Ollero M, Corringer PJ, Edelman A. Faure G, et al. Among authors: roldan a. J Mol Biol. 2016 Jul 17;428(14):2898-915. doi: 10.1016/j.jmb.2016.05.016. Epub 2016 May 27. J Mol Biol. 2016. PMID: 27241308

10

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

Premchandar A, Kupniewska A, Bonna A, Faure G, Fraczyk T, Roldan A, Hoffmann B, Faria da Cunha M, Herrmann H, Lukacs GL, Edelman A, Dadlez M. Premchandar A, et al. Among authors: roldan a. Protein Sci. 2017 Feb;26(2):343-354. doi: 10.1002/pro.3086. Protein Sci. 2017. PMID: 27870250 Free PMC article.

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