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A candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against Leishmania infantum infection.
Lage DP, Ribeiro PAF, Dias DS, Mendonça DVC, Ramos FF, Carvalho LM, de Oliveira D, Steiner BT, Martins VT, Perin L, Machado AS, Santos TTO, Tavares GSV, Oliveira-da-Silva JA, Oliveira JS, Roatt BM, Machado-de-Ávila RA, Teixeira AL, Humbert MV, Coelho EAF, Christodoulides M. Lage DP, et al. Among authors: santos tto. NPJ Vaccines. 2020 Aug 13;5:75. doi: 10.1038/s41541-020-00224-0. eCollection 2020. NPJ Vaccines. 2020. PMID: 32821440 Free PMC article.
Probing the efficacy of a heterologous Leishmania/L. Viannia braziliensis recombinant enolase as a candidate vaccine to restrict the development of L. infantum in BALB/c mice.
Santos TTO, Martins VT, Lage DP, Costa LE, Salles BCS, Carvalho AMRS, Dias DS, Ribeiro PAF, Chávez-Fumagalli MA, Machado-de-Ávila RA, Roatt BM, de Magalhães-Soares DF, Menezes-Souza D, Coelho EAF, Duarte MC. Santos TTO, et al. Acta Trop. 2017 Jul;171:8-16. doi: 10.1016/j.actatropica.2017.03.008. Epub 2017 Mar 10. Acta Trop. 2017. PMID: 28288798
Recombinant small glutamine-rich tetratricopeptide repeat-containing protein of Leishmania infantum: Potential vaccine and diagnostic application against visceral leishmaniasis.
Dias DS, Ribeiro PAF, Martins VT, Lage DP, Portela ÁSB, Costa LE, Salles BCS, Lima MP, Ramos FF, Santos TTO, Caligiorne RB, Chávez-Fumagalli MA, Silveira JAG, Magalhães-Soares DF, Gonçalves DU, Oliveira JS, Roatt BM, Duarte MC, Menezes-Souza D, Silva ES, Galdino AS, Machado-de-Ávila RA, Teixeira AL, Coelho EAF. Dias DS, et al. Among authors: santos tto. Mol Immunol. 2017 Nov;91:272-281. doi: 10.1016/j.molimm.2017.09.017. Epub 2017 Oct 5. Mol Immunol. 2017. PMID: 28988041
Recombinant prohibitin protein of Leishmania infantum acts as a vaccine candidate and diagnostic marker against visceral leishmaniasis.
Dias DS, Ribeiro PAF, Martins VT, Lage DP, Ramos FF, Dias ALT, Rodrigues MR, Portela ÁSB, Costa LE, Caligiorne RB, Steiner BT, Chávez-Fumagalli MA, Salles BCS, Santos TTO, Silveira JAG, Magalhães-Soares DF, Roatt BM, Machado-de-Ávila RA, Duarte MC, Menezes-Souza D, Silva ES, Galdino AS, Coelho EAF. Dias DS, et al. Among authors: santos tto. Cell Immunol. 2018 Jan;323:59-69. doi: 10.1016/j.cellimm.2017.11.001. Epub 2017 Nov 9. Cell Immunol. 2018. PMID: 29128045
Small Myristoylated Protein-3, Identified as a Potential Virulence Factor in Leishmania amazonensis, Proves to be a Protective Antigen against Visceral Leishmaniasis.
Oliveira MP, Martins VT, Santos TTO, Lage DP, Ramos FF, Salles BCS, Costa LE, Dias DS, Ribeiro PAF, Schneider MS, Machado-de-Ávila RA, Teixeira AL, Coelho EAF, Chávez-Fumagalli MA. Oliveira MP, et al. Among authors: santos tto. Int J Mol Sci. 2018 Jan 3;19(1):129. doi: 10.3390/ijms19010129. Int J Mol Sci. 2018. PMID: 29301342 Free PMC article.
Vaccination with a CD4+ and CD8+ T-cell epitopes-based recombinant chimeric protein derived from Leishmania infantum proteins confers protective immunity against visceral leishmaniasis.
Dias DS, Ribeiro PAF, Martins VT, Lage DP, Costa LE, Chávez-Fumagalli MA, Ramos FF, Santos TTO, Ludolf F, Oliveira JS, Mendes TAO, Silva ES, Galdino AS, Duarte MC, Roatt BM, Menezes-Souza D, Teixeira AL, Coelho EAF. Dias DS, et al. Among authors: santos tto. Transl Res. 2018 Oct;200:18-34. doi: 10.1016/j.trsl.2018.05.001. Epub 2018 May 22. Transl Res. 2018. PMID: 29908151
High-through identification of T cell-specific phage-exposed mimotopes using PBMCs from tegumentary leishmaniasis patients and their use as vaccine candidates against Leishmania amazonensis infection.
Carvalho GB, Costa LE, Lage DP, Ramos FF, Santos TTO, Ribeiro PAF, Dias DS, Salles BCS, Lima MP, Carvalho LM, Dias ACS, Alves PT, Franklin ML, Silva RAM, Duarte MC, Menezes-Souza D, Roatt BM, Chávez-Fumagalli MA, Goulart LR, Teixeira AL, Coelho EAF. Carvalho GB, et al. Among authors: santos tto. Parasitology. 2019 Mar;146(3):322-332. doi: 10.1017/S0031182018001403. Epub 2018 Sep 10. Parasitology. 2019. PMID: 30198459
Immunogenicity and protective efficacy of a new Leishmania hypothetical protein applied as a DNA vaccine or in a recombinant form against Leishmania infantum infection.
Ribeiro PAF, Dias DS, Lage DP, Martins VT, Costa LE, Santos TTO, Ramos FF, Tavares GSV, Mendonça DVC, Ludolf F, Gomes DA, Rodrigues MA, Chávez-Fumagalli MA, Silva ES, Galdino AS, Duarte MC, Roatt BM, Menezes-Souza D, Teixeira AL, Coelho EAF. Ribeiro PAF, et al. Among authors: santos tto. Mol Immunol. 2019 Feb;106:108-118. doi: 10.1016/j.molimm.2018.12.025. Epub 2018 Dec 27. Mol Immunol. 2019. PMID: 30594673
A biomarker for tegumentary and visceral leishmaniasis based on a recombinant Leishmania hypothetical protein.
Lage DP, Machado AS, Ramos FF, Silveira PC, Dias DS, Ribeiro PAF, Tavares GSV, Costa LE, Santos TTO, Steiner BT, Fagundes MI, Chávez-Fumagalli MA, Lyon S, Moreira RLF, Duarte MC, Menezes-Souza D, Caligiorne RB, Machado-de-Ávila RA, Teixeira AL, Coelho EAF. Lage DP, et al. Among authors: santos tto. Immunobiology. 2019 Jul;224(4):477-484. doi: 10.1016/j.imbio.2019.05.008. Epub 2019 May 30. Immunobiology. 2019. PMID: 31164242
A Leishmania infantum hypothetical protein evaluated as a recombinant protein and specific B-cell epitope for the serodiagnosis and prognosis of visceral leishmaniasis.
Machado AS, Ramos FF, Oliveira-da-Silva JA, Santos TTO, Ludolf F, Tavares GSV, Costa LE, Lage DP, Steiner BT, Chaves AT, Chávez-Fumagalli MA, de Magalhães-Soares DF, Silveira JAG, Napoles KMN, Tupinambás U, Duarte MC, Machado-de-Ávila RA, Bueno LL, Fujiwara RT, Moreira RLF, Rocha MOC, Caligiorne RB, Coelho EAF. Machado AS, et al. Among authors: santos tto. Acta Trop. 2020 Mar;203:105318. doi: 10.1016/j.actatropica.2019.105318. Epub 2019 Dec 20. Acta Trop. 2020. PMID: 31870709
38 results