Yoshimoto R - Search Results

1

Diacylglycerol acyltransferase 1/2 inhibition induces dysregulation of fatty acid metabolism and leads to intestinal barrier failure and diarrhea in mice.

Takemoto K, Fukasaka Y, Yoshimoto R, Nambu H, Yukioka H. Takemoto K, et al. Among authors: yoshimoto r. Physiol Rep. 2020 Aug;8(15):e14542. doi: 10.14814/phy2.14542. Physiol Rep. 2020. PMID: 32786057 Free PMC article.

2

Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice.

Kato A, Ito M, Sanaki T, Okuda T, Tsuchiya N, Yoshimoto R, Yukioka H. Kato A, et al. Among authors: yoshimoto r. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb;1867(2):159085. doi: 10.1016/j.bbalip.2021.159085. Epub 2021 Nov 20. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 34813948

3

Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors.

Hayashi K, Kondo N, Omori N, Yoshimoto R, Hato M, Shigaki S, Nagasawa A, Ito M, Okuno T. Hayashi K, et al. Among authors: yoshimoto r. Bioorg Med Chem Lett. 2021 Feb 1;33:127722. doi: 10.1016/j.bmcl.2020.127722. Epub 2020 Dec 4. Bioorg Med Chem Lett. 2021. PMID: 33285268

4

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.

Liu J, Gorski JN, Gold SJ, Chen D, Chen S, Forrest G, Itoh Y, Marsh DJ, McLaren DG, Shen Z, Sonatore L, Carballo-Jane E, Craw S, Guan X, Karanam B, Sakaki J, Szeto D, Tong X, Xiao J, Yoshimoto R, Yu H, Roddy TP, Balkovec J, Pinto S. Liu J, et al. Among authors: yoshimoto r. Obesity (Silver Spring). 2013 Jul;21(7):1406-15. doi: 10.1002/oby.20193. Epub 2013 May 13. Obesity (Silver Spring). 2013. PMID: 23671037 Free article.

5

Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors.

Mizutani T, Ishikawa S, Nagase T, Takahashi H, Fujimura T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Mizutani T, et al. Among authors: yoshimoto r. J Med Chem. 2009 Nov 26;52(22):7289-300. doi: 10.1021/jm900915x. J Med Chem. 2009. PMID: 19883081

6

Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.

Shimamura K, Nagumo A, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S. Shimamura K, et al. Among authors: yoshimoto r. Eur J Pharmacol. 2010 Mar 25;630(1-3):34-41. doi: 10.1016/j.ejphar.2009.12.033. Epub 2010 Jan 4. Eur J Pharmacol. 2010. PMID: 20045404

7

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Takahashi T, et al. Among authors: yoshimoto r. J Med Chem. 2009 May 28;52(10):3142-5. doi: 10.1021/jm900391x. J Med Chem. 2009. PMID: 19388647

8

Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion.

Okawa M, Fujii K, Ohbuchi K, Okumoto M, Aragane K, Sato H, Tamai Y, Seo T, Itoh Y, Yoshimoto R. Okawa M, et al. Among authors: yoshimoto r. Biochem Biophys Res Commun. 2009 Dec 18;390(3):377-81. doi: 10.1016/j.bbrc.2009.08.167. Epub 2009 Sep 2. Biochem Biophys Res Commun. 2009. PMID: 19732742

9

Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Sasaki T, Nagase T, Takahashi T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Sasaki T, et al. Among authors: yoshimoto r. Bioorg Med Chem. 2009 Aug 1;17(15):5639-47. doi: 10.1016/j.bmc.2009.06.042. Epub 2009 Jun 26. Bioorg Med Chem. 2009. PMID: 19596583

10

5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool.

Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S. Shimamura K, et al. Among authors: yoshimoto r. J Pharmacol Exp Ther. 2009 Jul;330(1):249-56. doi: 10.1124/jpet.109.150854. Epub 2009 Apr 9. J Pharmacol Exp Ther. 2009. PMID: 19359527

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

140 results

Search Page