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Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction.
Lan L, Liu J, Xing M, Smith AR, Wang J, Wu X, Appelman C, Li K, Roy A, Gowthaman R, Karanicolas J, Somoza AD, Wang CCC, Miao Y, De Guzman R, Oakley BR, Neufeld KL, Xu L. Lan L, et al. Among authors: karanicolas j. Cancers (Basel). 2020 Aug 8;12(8):2221. doi: 10.3390/cancers12082221. Cancers (Basel). 2020. PMID: 32784494 Free PMC article.
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.
Lan L, Appelman C, Smith AR, Yu J, Larsen S, Marquez RT, Liu H, Wu X, Gao P, Roy A, Anbanandam A, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Ji M, Cohen RS, Neufeld KL, Xu L. Lan L, et al. Among authors: karanicolas j. Mol Oncol. 2015 Aug;9(7):1406-20. doi: 10.1016/j.molonc.2015.03.014. Epub 2015 Apr 10. Mol Oncol. 2015. PMID: 25933687 Free PMC article.
Full and Partial Agonism of a Designed Enzyme Switch.
Budiardjo SJ, Licknack TJ, Cory MB, Kapros D, Roy A, Lovell S, Douglas J, Karanicolas J. Budiardjo SJ, et al. Among authors: karanicolas j. ACS Synth Biol. 2016 Dec 16;5(12):1475-1484. doi: 10.1021/acssynbio.6b00097. Epub 2016 Jul 22. ACS Synth Biol. 2016. PMID: 27389009 Free PMC article.
Identification of novel small molecule Beclin 1 mimetics activating autophagy.
Yu J, Lan L, Lewin SJ, Rogers SA, Roy A, Wu X, Gao P, Karanicolas J, Aubé J, Sun B, Xu L. Yu J, et al. Among authors: karanicolas j. Oncotarget. 2017 May 18;8(31):51355-51369. doi: 10.18632/oncotarget.17977. eCollection 2017 Aug 1. Oncotarget. 2017. PMID: 28881653 Free PMC article.
Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.
Lan L, Liu H, Smith AR, Appelman C, Yu J, Larsen S, Marquez RT, Wu X, Liu FY, Gao P, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Neufeld KL, Xu L. Lan L, et al. Among authors: karanicolas j. BMC Cancer. 2018 Aug 10;18(1):809. doi: 10.1186/s12885-018-4704-z. BMC Cancer. 2018. PMID: 30097032 Free PMC article.
74 results