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p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Nat Chem Biol. 2020 Oct;16(10):1078-1086. doi: 10.1038/s41589-020-0600-3. Epub 2020 Jul 27.
Nat Chem Biol. 2020.
PMID: 32719556
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation.
Fester N, Zielonka E, Goldmann J, Frombach AS, Müller-Kuller U, Gutfreund N, Riegel K, Smits JGA, Schleiff E, Rajalingam K, Zhou H, Simm S, Dötsch V.
Fester N, et al. Among authors: gutfreund n.
Cell Death Dis. 2022 Mar 4;13(3):204. doi: 10.1038/s41419-022-04659-2.
Cell Death Dis. 2022.
PMID: 35246516
Free PMC article.
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A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1.
Raab M, Matthess Y, Raab CA, Gutfreund N, Dötsch V, Becker S, Sanhaji M, Strebhardt K.
Raab M, et al. Among authors: gutfreund n.
Oncogene. 2022 Jan;41(3):372-386. doi: 10.1038/s41388-021-02094-9. Epub 2021 Nov 10.
Oncogene. 2022.
PMID: 34759346
Free PMC article.
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Dominant TP63 missense variants lead to constitutive activation and premature ovarian insufficiency.
Tucker EJ, Gutfreund N, Belaud-Rotureau MA, Gilot D, Brun T, Kline BL, Bell KM, Domin-Bernhard M, Théard C, Touraine P, Robevska G, van van den Bergen J, Ayers KL, Sinclair AH, Dötsch V, Jaillard S.
Tucker EJ, et al. Among authors: gutfreund n.
Hum Mutat. 2022 Oct;43(10):1443-1453. doi: 10.1002/humu.24432. Epub 2022 Jul 29.
Hum Mutat. 2022.
PMID: 35801529
Free PMC article.
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Development of NanoBRET-Binding Assays for FKBP-Ligand Profiling in Living Cells.
Gnatzy MT, Geiger TM, Kuehn A, Gutfreund N, Walz M, Kolos JM, Hausch F.
Gnatzy MT, et al. Among authors: gutfreund n.
Chembiochem. 2021 Jul 1;22(13):2257-2261. doi: 10.1002/cbic.202100113. Epub 2021 May 14.
Chembiochem. 2021.
PMID: 33887102
Free PMC article.
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Correction: A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1.
Raab M, Matthess Y, Raab CA, Gutfreund N, Dötsch V, Becker S, Sanhaji M, Strebhardt K.
Raab M, et al. Among authors: gutfreund n.
Oncogene. 2023 Aug;42(34):2590. doi: 10.1038/s41388-023-02779-3.
Oncogene. 2023.
PMID: 37488194
Free PMC article.
No abstract available.
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