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Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain.
MAbs. 2020 Jan-Dec;12(1):1787121. doi: 10.1080/19420862.2020.1787121.
MAbs. 2020.
PMID: 32658605
Free PMC article.
Prediction and Reduction of the Aggregation of Monoclonal Antibodies.
van der Kant R, Karow-Zwick AR, Van Durme J, Blech M, Gallardo R, Seeliger D, Aßfalg K, Baatsen P, Compernolle G, Gils A, Studts JM, Schulz P, Garidel P, Schymkowitz J, Rousseau F.
van der Kant R, et al. Among authors: karow zwick ar.
J Mol Biol. 2017 Apr 21;429(8):1244-1261. doi: 10.1016/j.jmb.2017.03.014. Epub 2017 Mar 18.
J Mol Biol. 2017.
PMID: 28322916
Free PMC article.
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High-concentration protein formulations: How high is high?
Garidel P, Kuhn AB, Schäfer LV, Karow-Zwick AR, Blech M.
Garidel P, et al. Among authors: karow zwick ar.
Eur J Pharm Biopharm. 2017 Oct;119:353-360. doi: 10.1016/j.ejpb.2017.06.029. Epub 2017 Jul 6.
Eur J Pharm Biopharm. 2017.
PMID: 28690199
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Improved Solution-State Properties of Monoclonal Antibodies by Targeted Mutations.
Kuhn AB, Kube S, Karow-Zwick AR, Seeliger D, Garidel P, Blech M, Schäfer LV.
Kuhn AB, et al. Among authors: karow zwick ar.
J Phys Chem B. 2017 Dec 7;121(48):10818-10827. doi: 10.1021/acs.jpcb.7b09126. Epub 2017 Nov 29.
J Phys Chem B. 2017.
PMID: 29135256
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Adaption of human antibody λ and κ light chain architectures to CDR repertoires.
van der Kant R, Bauer J, Karow-Zwick AR, Kube S, Garidel P, Blech M, Rousseau F, Schymkowitz J.
van der Kant R, et al. Among authors: karow zwick ar.
Protein Eng Des Sel. 2019 Dec 13;32(3):109-127. doi: 10.1093/protein/gzz012.
Protein Eng Des Sel. 2019.
PMID: 31535139
Free PMC article.
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Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches.
Hoffmann D, Bauer J, Kossner M, Henry A, Karow-Zwick AR, Licari G.
Hoffmann D, et al. Among authors: karow zwick ar.
MAbs. 2024 Jan-Dec;16(1):2333436. doi: 10.1080/19420862.2024.2333436. Epub 2024 Mar 28.
MAbs. 2024.
PMID: 38546837
Free PMC article.
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Embedding Dynamics in Intrinsic Physicochemical Profiles of Market-Stage Antibody-Based Biotherapeutics.
Licari G, Martin KP, Crames M, Mozdzierz J, Marlow MS, Karow-Zwick AR, Kumar S, Bauer J.
Licari G, et al. Among authors: karow zwick ar.
Mol Pharm. 2023 Feb 6;20(2):1096-1111. doi: 10.1021/acs.molpharmaceut.2c00838. Epub 2022 Dec 27.
Mol Pharm. 2023.
PMID: 36573887
Free PMC article.
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