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Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease.
Ratni H, Alker A, Bartels B, Bissantz C, Chen W, Gerlach I, Limberg A, Lu M, Neidhart W, Pichereau S, Reutlinger M, Rodriguez-Sarmiento RM, Jakob-Roetne R, Schmitt G, Zhang E, Baumann K. Ratni H, et al. Among authors: limberg a. ACS Med Chem Lett. 2020 Apr 27;11(6):1257-1268. doi: 10.1021/acsmedchemlett.0c00109. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551009 Free PMC article.
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.
Rawson TE, Rüth M, Blackwood E, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Georges GJ, Goller B, Halladay J, Hunsaker T, Kleinheinz T, Krell HW, Li J, Liang J, Limberg A, McNutt A, Moffat J, Phillips G, Ran Y, Safina B, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhou A, Zhu BY, Rüger P, Cochran AG. Rawson TE, et al. Among authors: limberg a. J Med Chem. 2008 Aug 14;51(15):4465-75. doi: 10.1021/jm800052b. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630890
AdipoRon reduces TGFβ1-mediated collagen deposition in vitro and alleviates knee stiffness in vivo.
Dudakovic A, Limberg AK, Bothun CE, Dilger OB, Bayram B, Bettencourt JW, Salmons HI, Thaler R, Karczewski DC, Owen AR, Iyer VG, Payne AN, Carstens MF, van Wijnen AJ, Berry DJ, Sanchez-Sotelo J, Morrey ME, Abdel MP. Dudakovic A, et al. Among authors: limberg ak. J Cell Physiol. 2024 Feb;239(2):e31168. doi: 10.1002/jcp.31168. Epub 2023 Dec 27. J Cell Physiol. 2024. PMID: 38149794
The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity.
Müller S, Sicorello M, Moser D, Frach L, Limberg A, Gumpp AM, Ramo-Fernandez L, Köhler-Dauner F, Fegert JM, Waller C, Kumsta R, Kolassa IT. Müller S, et al. Among authors: limberg a. Transl Psychiatry. 2023 Jul 21;13(1):265. doi: 10.1038/s41398-023-02548-6. Transl Psychiatry. 2023. PMID: 37479681 Free PMC article.
The Safety of Adiponectin Receptor Agonist AdipoRon in a Rabbit Model of Arthrofibrosis.
Salmons HI, Gow C, Limberg AK, Bettencourt JW, Carstens MF, Payne AN, Morrey ME, Sanchez-Sotelo J, Berry DJ, Dudakovic A, Abdel MP. Salmons HI, et al. Among authors: limberg ak. Tissue Eng Part C Methods. 2023 Apr;29(4):154-159. doi: 10.1089/ten.TEC.2023.0008. Tissue Eng Part C Methods. 2023. PMID: 36924279 Free PMC article.
Knee immobilization reproduces key arthrofibrotic phenotypes in mice.
Dagneaux L, Limberg AK, Owen AR, Bettencourt JW, Dudakovic A, Bayram B, Gades NM, Sanchez-Sotelo J, Berry DJ, van Wijnen A, Morrey ME, Abdel MP. Dagneaux L, et al. Among authors: limberg ak. Bone Joint Res. 2023 Jan;12(1):58-71. doi: 10.1302/2046-3758.121.BJR-2022-0250.R2. Bone Joint Res. 2023. PMID: 36647696 Free PMC article.
86 results