Bissantz C - Search Results

1

Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease.

Ratni H, Alker A, Bartels B, Bissantz C, Chen W, Gerlach I, Limberg A, Lu M, Neidhart W, Pichereau S, Reutlinger M, Rodriguez-Sarmiento RM, Jakob-Roetne R, Schmitt G, Zhang E, Baumann K. Ratni H, et al. Among authors: bissantz c. ACS Med Chem Lett. 2020 Apr 27;11(6):1257-1268. doi: 10.1021/acsmedchemlett.0c00109. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551009 Free PMC article.

2

Me-talnetant and osanetant interact within overlapping but not identical binding pockets in the human tachykinin neurokinin 3 receptor transmembrane domains.

Malherbe P, Bissantz C, Marcuz A, Kratzeisen C, Zenner MT, Wettstein JG, Ratni H, Riemer C, Spooren W. Malherbe P, et al. Among authors: bissantz c. Mol Pharmacol. 2008 Jun;73(6):1736-50. doi: 10.1124/mol.107.042754. Epub 2008 Feb 28. Mol Pharmacol. 2008. PMID: 18308898

3

Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.

Malherbe P, Kratzeisen C, Marcuz A, Zenner MT, Nettekoven MH, Ratni H, Wettstein JG, Bissantz C. Malherbe P, et al. Among authors: bissantz c. J Med Chem. 2009 Nov 26;52(22):7103-12. doi: 10.1021/jm900948q. J Med Chem. 2009. PMID: 19817444

4

Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.

Malherbe P, Knoflach F, Marcuz A, Bohnert C, Weber M, Knust H, Ratni H, Spooren W, Ballard TM, Bissantz C. Malherbe P, et al. Among authors: bissantz c. Neuropharmacology. 2014 Nov;86:259-72. doi: 10.1016/j.neuropharm.2014.07.017. Epub 2014 Aug 5. Neuropharmacology. 2014. PMID: 25107588

5

Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.

Ratni H, Rogers-Evans M, Bissantz C, Grundschober C, Moreau JL, Schuler F, Fischer H, Alvarez Sanchez R, Schnider P. Ratni H, et al. Among authors: bissantz c. J Med Chem. 2015 Mar 12;58(5):2275-89. doi: 10.1021/jm501745f. Epub 2015 Feb 18. J Med Chem. 2015. PMID: 25654260

6

A Real-World Perspective on Molecular Design.

Kuhn B, Guba W, Hert J, Banner D, Bissantz C, Ceccarelli S, Haap W, Körner M, Kuglstatter A, Lerner C, Mattei P, Neidhart W, Pinard E, Rudolph MG, Schulz-Gasch T, Woltering T, Stahl M. Kuhn B, et al. Among authors: bissantz c. J Med Chem. 2016 May 12;59(9):4087-102. doi: 10.1021/acs.jmedchem.5b01875. Epub 2016 Feb 24. J Med Chem. 2016. PMID: 26878596

7

Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder.

Schnider P, Bissantz C, Bruns A, Dolente C, Goetschi E, Jakob-Roetne R, Künnecke B, Mueggler T, Muster W, Parrott N, Pinard E, Ratni H, Risterucci C, Rogers-Evans M, von Kienlin M, Grundschober C. Schnider P, et al. Among authors: bissantz c. J Med Chem. 2020 Feb 27;63(4):1511-1525. doi: 10.1021/acs.jmedchem.9b01478. Epub 2020 Jan 17. J Med Chem. 2020. PMID: 31951127

8

Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere.

Rodríguez Sarmiento RM, Bissantz C, Bylund J, Limberg A, Neidhart W, Jakob-Roetne R, Wang L, Baumann K. Rodríguez Sarmiento RM, et al. Among authors: bissantz c. J Med Chem. 2020 Aug 13;63(15):8534-8553. doi: 10.1021/acs.jmedchem.0c00909. Epub 2020 Aug 4. J Med Chem. 2020. PMID: 32706964

9

From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.

Guba W, Green LG, Martin RE, Roche O, Kratochwil N, Mauser H, Bissantz C, Christ A, Stahl M. Guba W, et al. Among authors: bissantz c. J Med Chem. 2007 Dec 13;50(25):6295-8. doi: 10.1021/jm701144e. Epub 2007 Nov 19. J Med Chem. 2007. PMID: 18020391

10

A medicinal chemist's guide to molecular interactions.

Bissantz C, Kuhn B, Stahl M. Bissantz C, et al. J Med Chem. 2010 Jul 22;53(14):5061-84. doi: 10.1021/jm100112j. J Med Chem. 2010. PMID: 20345171 Free PMC article. Review. No abstract available.

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