Flarakos J - Search Results

1

Development and validation of an LC-MS/MS method for the quantitative analysis of the adenosine A2a receptor antagonist NIR178 and its monohydroxy metabolite in human plasma: Application to clinical pharmacokinetics.

Heudi O, Plaud N, Aumonier C, Wu S, Hatsis P, Hurtado FK, Picard F, Winter S, Flarakos J. Heudi O, et al. Among authors: flarakos j. Biomed Chromatogr. 2020 Oct;34(10):e4909. doi: 10.1002/bmc.4909. Epub 2020 Jul 6. Biomed Chromatogr. 2020. PMID: 32485782 Clinical Trial.

2

Evaluation, identification and impact assessment of abnormal internal standard response variability in regulated LC-MS bioanalysis.

Fu Y, Barkley D, Li W, Picard F, Flarakos J. Fu Y, et al. Among authors: flarakos j. Bioanalysis. 2020 Apr;12(8):545-559. doi: 10.4155/bio-2020-0058. Epub 2020 Apr 30. Bioanalysis. 2020. PMID: 32352315 Free article. Review.

3

Dixon's Q-test and Student's t-test to assess analog internal standard response in nonregulated LC-MS/MS bioanalysis.

Barkley D, Hatsis P, Glick J, Li W, Flarakos J. Barkley D, et al. Among authors: flarakos j. Bioanalysis. 2020 Nov;12(21):1535-1543. doi: 10.4155/bio-2020-0207. Epub 2020 Oct 16. Bioanalysis. 2020. PMID: 33064023

4

An integrated outsourcing practice of nonclinical LC-MS bioanalysis and toxicokinetics at Novartis small molecule drug development.

Li W, Glick J, Hatsis P, Fu Y, Chin H, Moench P, Flarakos J. Li W, et al. Among authors: flarakos j. Bioanalysis. 2021 Jun;13(12):1001-1010. doi: 10.4155/bio-2021-0072. Epub 2021 Jun 3. Bioanalysis. 2021. PMID: 34081547

5

Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry.

Chen X, Hatsis P, Judge J, Argikar UA, Ren X, Sarber J, Mansfield K, Liang G, Amaral A, Catoire A, Bentley A, Ramos L, Moench P, Hintermann S, Carcache D, Glick J, Flarakos J. Chen X, et al. Among authors: flarakos j. Anal Chem. 2016 Dec 6;88(23):11813-11820. doi: 10.1021/acs.analchem.6b03449. Epub 2016 Nov 16. Anal Chem. 2016. PMID: 27797491

6

Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography-tandem mass spectrometry.

Li W, Doherty J, Fu Y, Flarakos J. Li W, et al. Among authors: flarakos j. Biomed Chromatogr. 2018 Feb;32(2). doi: 10.1002/bmc.4068. Epub 2017 Sep 20. Biomed Chromatogr. 2018. PMID: 28833263

7

LC-MS/MS determination of a human mAb drug candidate in rat serum using an isotopically labeled universal mAb internal standard.

Li W, Lin H, Fu Y, Flarakos J. Li W, et al. Among authors: flarakos j. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15;1044-1045:166-176. doi: 10.1016/j.jchromb.2016.12.044. Epub 2017 Jan 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28113139

8

Highly selective and sensitive LC-MS/MS quantification of a therapeutic protein in human serum using immunoaffinity capture enrichment.

Fu Y, Li W, Flarakos J. Fu Y, et al. Among authors: flarakos j. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Nov 15;1100-1101:83-90. doi: 10.1016/j.jchromb.2018.09.040. Epub 2018 Oct 2. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 30296718

9

A semi-automated LC-MS/MS method for the determination of LCI699, a steroid 11β-hydroxylase inhibitor, in human plasma.

Li W, Luo S, Rebello S, Flarakos J, Tse FL. Li W, et al. Among authors: flarakos j. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1;960:182-93. doi: 10.1016/j.jchromb.2014.04.012. Epub 2014 Apr 30. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. PMID: 24814004

10

LC-MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study.

Li W, Doherty J, Moench P, Flarakos J, Tse FL. Li W, et al. Among authors: flarakos j. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 1;983-984:117-24. doi: 10.1016/j.jchromb.2014.12.033. Epub 2015 Jan 13. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25645810 Clinical Trial.

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