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EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair.
Koyen AE, Madden MZ, Park D, Minten EV, Kapoor-Vazirani P, Werner E, Pfister NT, Haji-Seyed-Javadi R, Zhang H, Xu J, Deng N, Duong DM, Pecen TJ, Frazier Z, Nagel ZD, Lazaro JB, Mouw KW, Seyfried NT, Moreno CS, Owonikoko TK, Deng X, Yu DS. Koyen AE, et al. Among authors: yu ds. Oncogene. 2020 Jun;39(25):4798-4813. doi: 10.1038/s41388-020-1332-2. Epub 2020 May 26. Oncogene. 2020. PMID: 32457468 Free PMC article.
SIRT2 directs the replication stress response through CDK9 deacetylation.
Zhang H, Park SH, Pantazides BG, Karpiuk O, Warren MD, Hardy CW, Duong DM, Park SJ, Kim HS, Vassilopoulos A, Seyfried NT, Johnsen SA, Gius D, Yu DS. Zhang H, et al. Among authors: yu ds. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13546-51. doi: 10.1073/pnas.1301463110. Epub 2013 Jul 29. Proc Natl Acad Sci U S A. 2013. PMID: 23898190 Free PMC article.
Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.
Hall WA, Petrova AV, Colbert LE, Hardy CW, Fisher SB, Saka B, Shelton JW, Warren MD, Pantazides BG, Gandhi K, Kowalski J, Kooby DA, El-Rayes BF, Staley CA 3rd, Volkan Adsay N, Curran WJ, Landry JC, Maithel SK, Yu DS. Hall WA, et al. Among authors: yu ds. Oncogene. 2014 Nov 20;33(47):5450-6. doi: 10.1038/onc.2013.488. Epub 2013 Nov 25. Oncogene. 2014. PMID: 24276239 Clinical Trial.
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer.
Colbert LE, Petrova AV, Fisher SB, Pantazides BG, Madden MZ, Hardy CW, Warren MD, Pan Y, Nagaraju GP, Liu EA, Saka B, Hall WA, Shelton JW, Gandhi K, Pauly R, Kowalski J, Kooby DA, El-Rayes BF, Staley CA 3rd, Adsay NV, Curran WJ Jr, Landry JC, Maithel SK, Yu DS. Colbert LE, et al. Among authors: yu ds. Cancer Res. 2014 May 15;74(10):2677-87. doi: 10.1158/0008-5472.CAN-13-1996. Epub 2014 Mar 13. Cancer Res. 2014. PMID: 24626090 Free PMC article.
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS. Zhang H, et al. Among authors: yu b, yu ds. Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4. Cell Rep. 2016. PMID: 26854234 Free PMC article.
SIRT2 orchestrates the DNA damage response.
Zhang H, Head PE, Yu DS. Zhang H, et al. Among authors: yu ds. Cell Cycle. 2016 Aug 17;15(16):2089-2090. doi: 10.1080/15384101.2016.1184517. Epub 2016 May 6. Cell Cycle. 2016. PMID: 27153288 Free PMC article. No abstract available.
638 results