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EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair.
Koyen AE, Madden MZ, Park D, Minten EV, Kapoor-Vazirani P, Werner E, Pfister NT, Haji-Seyed-Javadi R, Zhang H, Xu J, Deng N, Duong DM, Pecen TJ, Frazier Z, Nagel ZD, Lazaro JB, Mouw KW, Seyfried NT, Moreno CS, Owonikoko TK, Deng X, Yu DS. Koyen AE, et al. Among authors: deng x, deng n. Oncogene. 2020 Jun;39(25):4798-4813. doi: 10.1038/s41388-020-1332-2. Epub 2020 May 26. Oncogene. 2020. PMID: 32457468 Free PMC article.
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS. Daddacha W, et al. Among authors: deng x. Cell Rep. 2017 Aug 22;20(8):1921-1935. doi: 10.1016/j.celrep.2017.08.008. Cell Rep. 2017. PMID: 28834754 Free PMC article.
Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.
Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Satola SW, Ramalingam SS, Curran WJ, Doetsch PW, Deng X. Chen G, et al. Among authors: deng x. J Clin Invest. 2018 Jan 2;128(1):500-516. doi: 10.1172/JCI92742. Epub 2017 Dec 11. J Clin Invest. 2018. PMID: 29227281 Free PMC article.
Mcl-1 Interacts with Akt to Promote Lung Cancer Progression.
Chen G, Park D, Magis AT, Behera M, Ramalingam SS, Owonikoko TK, Sica GL, Ye K, Zhang C, Chen Z, Curran WJ, Deng X. Chen G, et al. Among authors: deng x. Cancer Res. 2019 Dec 15;79(24):6126-6138. doi: 10.1158/0008-5472.CAN-19-0950. Epub 2019 Oct 29. Cancer Res. 2019. PMID: 31662324 Free PMC article.
Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both.
Ma G, Deng Y, Qian L, Vallega KA, Zhang G, Deng X, Owonikoko TK, Ramalingam SS, Fang DD, Zhai Y, Sun SY. Ma G, et al. Among authors: deng y, deng x. Oncogene. 2022 Mar;41(12):1691-1700. doi: 10.1038/s41388-022-02200-5. Epub 2022 Jan 31. Oncogene. 2022. PMID: 35102249 Free PMC article.
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS. Zhang H, et al. Among authors: deng x. Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4. Cell Rep. 2016. PMID: 26854234 Free PMC article.
Discovery of Small Molecule Bak Activator for Lung Cancer Therapy.
Park D, Anisuzzaman ASM, Magis AT, Chen G, Xie M, Zhang G, Behera M, Sica GL, Ramalingam SS, Owonikoko TK, Deng X. Park D, et al. Among authors: deng x. Theranostics. 2021 Jul 25;11(17):8500-8516. doi: 10.7150/thno.60349. eCollection 2021. Theranostics. 2021. PMID: 34373755 Free PMC article.
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