Hirst J - Search Results

1

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.

Stephenson ZA, Harvey RF, Pryde KR, Mistry S, Hardy RE, Serreli R, Chung I, Allen TE, Stoneley M, MacFarlane M, Fischer PM, Hirst J, Kellam B, Willis AE. Stephenson ZA, et al. Among authors: hirst j. Elife. 2020 May 20;9:e55845. doi: 10.7554/eLife.55845. Elife. 2020. PMID: 32432547 Free PMC article.

2

The production of reactive oxygen species by complex I.

Hirst J, King MS, Pryde KR. Hirst J, et al. Biochem Soc Trans. 2008 Oct;36(Pt 5):976-80. doi: 10.1042/BST0360976. Biochem Soc Trans. 2008. PMID: 18793173

3

Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer.

Pryde KR, Hirst J. Pryde KR, et al. Among authors: hirst j. J Biol Chem. 2011 May 20;286(20):18056-65. doi: 10.1074/jbc.M110.186841. Epub 2011 Mar 10. J Biol Chem. 2011. PMID: 21393237 Free PMC article.

4

Why does mitochondrial complex I have so many subunits?

Hirst J. Hirst J. Biochem J. 2011 Jul 15;437(2):e1-3. doi: 10.1042/BJ20110918. Biochem J. 2011. PMID: 21711245

5

Mitochondrial complex I.

Hirst J. Hirst J. Annu Rev Biochem. 2013;82:551-75. doi: 10.1146/annurev-biochem-070511-103700. Epub 2013 Mar 18. Annu Rev Biochem. 2013. PMID: 23527692 Review.

6

Architecture of mammalian respiratory complex I.

Vinothkumar KR, Zhu J, Hirst J. Vinothkumar KR, et al. Among authors: hirst j. Nature. 2014 Nov 6;515(7525):80-84. doi: 10.1038/nature13686. Epub 2014 Sep 7. Nature. 2014. PMID: 25209663 Free PMC article.

7

Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes.

Blaza JN, Serreli R, Jones AJ, Mohammed K, Hirst J. Blaza JN, et al. Among authors: hirst j. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15735-40. doi: 10.1073/pnas.1413855111. Epub 2014 Oct 20. Proc Natl Acad Sci U S A. 2014. PMID: 25331896 Free PMC article.

8

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.

Bridges HR, Sirviö VA, Agip AN, Hirst J. Bridges HR, et al. Among authors: hirst j. BMC Biol. 2016 Aug 9;14:65. doi: 10.1186/s12915-016-0287-9. BMC Biol. 2016. PMID: 27506389 Free PMC article.

9

Structure of mammalian respiratory complex I.

Zhu J, Vinothkumar KR, Hirst J. Zhu J, et al. Among authors: hirst j. Nature. 2016 Aug 18;536(7616):354-358. doi: 10.1038/nature19095. Epub 2016 Aug 10. Nature. 2016. PMID: 27509854 Free PMC article.

10

An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. Molina JR, et al. Among authors: hirst j. Nat Med. 2018 Jul;24(7):1036-1046. doi: 10.1038/s41591-018-0052-4. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892070

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