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Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke.
Titz B, Szostak J, Sewer A, Phillips B, Nury C, Schneider T, Dijon S, Lavrynenko O, Elamin A, Guedj E, Tsin Wong E, Lebrun S, Vuillaume G, Kondylis A, Gubian S, Cano S, Leroy P, Keppler B, Ivanov NV, Vanscheeuwijck P, Martin F, Peitsch MC, Hoeng J. Titz B, et al. Among authors: lebrun s. Comput Struct Biotechnol J. 2020 Apr 25;18:1056-1073. doi: 10.1016/j.csbj.2020.04.011. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32419906 Free PMC article.
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.
Titz B, Kogel U, Martin F, Schlage WK, Xiang Y, Nury C, Dijon S, Baumer K, Peric D, Bornand D, Dulize R, Phillips B, Leroy P, Vuillaume G, Lebrun S, Elamin A, Guedj E, Trivedi K, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J. Titz B, et al. Among authors: lebrun s. Food Chem Toxicol. 2018 May;115:284-301. doi: 10.1016/j.fct.2018.02.058. Epub 2018 Mar 13. Food Chem Toxicol. 2018. PMID: 29545142 Free article.
Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.
Boué S, De León H, Schlage WK, Peck MJ, Weiler H, Berges A, Vuillaume G, Martin F, Friedrichs B, Lebrun S, Meurrens K, Schracke N, Moehring M, Steffen Y, Schueller J, Vanscheeuwijck P, Peitsch MC, Hoeng J. Boué S, et al. Among authors: lebrun s. Toxicology. 2013 Dec 6;314(1):112-24. doi: 10.1016/j.tox.2013.09.013. Epub 2013 Oct 1. Toxicology. 2013. PMID: 24096154 Free article.
Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.
Kogel U, Titz B, Schlage WK, Nury C, Martin F, Oviedo A, Lebrun S, Elamin A, Guedj E, Trivedi K, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J. Kogel U, et al. Among authors: lebrun s. Regul Toxicol Pharmacol. 2016 Nov 30;81 Suppl 2:S123-S138. doi: 10.1016/j.yrtph.2016.11.001. Epub 2016 Nov 4. Regul Toxicol Pharmacol. 2016. PMID: 27818347 Free article.
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.
Oviedo A, Lebrun S, Kogel U, Ho J, Tan WT, Titz B, Leroy P, Vuillaume G, Bera M, Martin F, Rodrigo G, Esposito M, Dempsey R, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P. Oviedo A, et al. Among authors: lebrun s. Regul Toxicol Pharmacol. 2016 Nov 30;81 Suppl 2:S93-S122. doi: 10.1016/j.yrtph.2016.11.004. Epub 2016 Nov 3. Regul Toxicol Pharmacol. 2016. PMID: 27818348 Free article.
Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.
Phillips B, Titz B, Kogel U, Sharma D, Leroy P, Xiang Y, Vuillaume G, Lebrun S, Sciuscio D, Ho J, Nury C, Guedj E, Elamin A, Esposito M, Krishnan S, Schlage WK, Veljkovic E, Ivanov NV, Martin F, Peitsch MC, Hoeng J, Vanscheeuwijck P. Phillips B, et al. Among authors: lebrun s. Food Chem Toxicol. 2017 Nov;109(Pt 1):315-332. doi: 10.1016/j.fct.2017.09.001. Epub 2017 Sep 5. Food Chem Toxicol. 2017. PMID: 28882640 Free article.
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague-Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis.
Ho J, Sciuscio D, Kogel U, Titz B, Leroy P, Vuillaume G, Talikka M, Martin E, Pospisil P, Lebrun S, Xia W, Lee T, Chng YX, Phillips BW, Veljkovic E, Guedj E, Xiang Y, Ivanov NV, Peitsch MC, Hoeng J, Vanscheeuwijck P. Ho J, et al. Among authors: lebrun s. Arch Toxicol. 2020 Jun;94(6):2179-2206. doi: 10.1007/s00204-020-02759-6. Epub 2020 May 5. Arch Toxicol. 2020. PMID: 32367274 Free PMC article.
Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation.
Lietz M, Berges A, Lebrun S, Meurrens K, Steffen Y, Stolle K, Schueller J, Boue S, Vuillaume G, Vanscheeuwijck P, Moehring M, Schlage W, De Leon H, Hoeng J, Peitsch M. Lietz M, et al. Among authors: lebrun s. Atherosclerosis. 2013 Jul;229(1):86-93. doi: 10.1016/j.atherosclerosis.2013.03.036. Epub 2013 Apr 22. Atherosclerosis. 2013. PMID: 23669247 Free article.
Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis.
Poussin C, Gallitz I, Schlage WK, Steffen Y, Stolle K, Lebrun S, Hoeng J, Peitsch MC, Lietz M. Poussin C, et al. Among authors: lebrun s. Toxicol In Vitro. 2014 Aug;28(5):896-908. doi: 10.1016/j.tiv.2014.03.005. Epub 2014 Apr 18. Toxicol In Vitro. 2014. PMID: 24747719 Free article.
88 results