Brown PA - Search Results

1

Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia.

Loftus JP, Yahiaoui A, Brown PA, Niswander LM, Bagashev A, Wang M, Schauf A, Tannheimer S, Tasian SK. Loftus JP, et al. Among authors: brown pa. Haematologica. 2021 Apr 1;106(4):1067-1078. doi: 10.3324/haematol.2019.241729. Haematologica. 2021. PMID: 32414848 Free PMC article.

2

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.

Brown P, Levis M, Shurtleff S, Campana D, Downing J, Small D. Brown P, et al. Blood. 2005 Jan 15;105(2):812-20. doi: 10.1182/blood-2004-06-2498. Epub 2004 Sep 16. Blood. 2005. PMID: 15374878 Free article.

3

Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner.

Brown P, Levis M, McIntyre E, Griesemer M, Small D. Brown P, et al. Leukemia. 2006 Aug;20(8):1368-76. doi: 10.1038/sj.leu.2404277. Epub 2006 Jun 8. Leukemia. 2006. PMID: 16761017

4

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.

Schafer E, Irizarry R, Negi S, McIntyre E, Small D, Figueroa ME, Melnick A, Brown P. Schafer E, et al. Blood. 2010 Jun 10;115(23):4798-809. doi: 10.1182/blood-2009-09-243634. Epub 2010 Mar 9. Blood. 2010. PMID: 20215641 Free PMC article.

5

MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism.

Sison EA, Rau RE, McIntyre E, Li L, Small D, Brown P. Sison EA, et al. Br J Haematol. 2013 Mar;160(6):785-97. doi: 10.1111/bjh.12205. Epub 2013 Jan 7. Br J Haematol. 2013. PMID: 23294096 Free PMC article.

6

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition.

Sison EA, Magoon D, Li L, Annesley CE, Rau RE, Small D, Brown P. Sison EA, et al. Oncotarget. 2014 Oct 15;5(19):8947-58. doi: 10.18632/oncotarget.2407. Oncotarget. 2014. PMID: 25333254 Free PMC article.

7

Treatment of pediatric acute lymphoblastic leukemia.

Cooper SL, Brown PA. Cooper SL, et al. Among authors: brown pa. Pediatr Clin North Am. 2015 Feb;62(1):61-73. doi: 10.1016/j.pcl.2014.09.006. Epub 2014 Oct 18. Pediatr Clin North Am. 2015. PMID: 25435112 Free PMC article. Review.

8

A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011).

Loh ML, Tasian SK, Rabin KR, Brown P, Magoon D, Reid JM, Chen X, Ahern CH, Weigel BJ, Blaney SM. Loh ML, et al. Pediatr Blood Cancer. 2015 Oct;62(10):1717-24. doi: 10.1002/pbc.25575. Epub 2015 May 13. Pediatr Blood Cancer. 2015. PMID: 25976292 Free PMC article. Clinical Trial.

9

rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.

Negi SS, Brown P. Negi SS, et al. Oncotarget. 2015 Jul 20;6(20):18094-104. doi: 10.18632/oncotarget.4093. Oncotarget. 2015. PMID: 26061708 Free PMC article.

10

POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL.

Sison EA, Magoon D, Li L, Annesley CE, Romagnoli B, Douglas GJ, Tuffin G, Zimmermann J, Brown P. Sison EA, et al. Oncotarget. 2015 Oct 13;6(31):30902-18. doi: 10.18632/oncotarget.5094. Oncotarget. 2015. PMID: 26360610 Free PMC article.

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