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Page 1
Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum †.
Diukendjieva A, Zaharieva MM, Mori M, Alov P, Tsakovska I, Pencheva T, Najdenski H, Křen V, Felici C, Bufalieri F, Di Marcotullio L, Botta B, Botta M, Pajeva I. Diukendjieva A, et al. Among authors: di marcotullio l. Antioxidants (Basel). 2020 May 5;9(5):384. doi: 10.3390/antiox9050384. Antioxidants (Basel). 2020. PMID: 32380762 Free PMC article.
Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma.
Lucarini V, Melaiu O, D'Amico S, Pastorino F, Tempora P, Scarsella M, Pezzullo M, De Ninno A, D'Oria V, Cilli M, Emionite L, Infante P, Di Marcotullio L, De Ioris MA, Barillari G, Alaggio R, Businaro L, Ponzoni M, Locatelli F, Fruci D. Lucarini V, et al. Among authors: di marcotullio l. J Exp Clin Cancer Res. 2022 Nov 17;41(1):326. doi: 10.1186/s13046-022-02525-9. J Exp Clin Cancer Res. 2022. PMID: 36397148 Free PMC article.
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.
Infante P, Mori M, Alfonsi R, Ghirga F, Aiello F, Toscano S, Ingallina C, Siler M, Cucchi D, Po A, Miele E, D'Amico D, Canettieri G, De Smaele E, Ferretti E, Screpanti I, Uccello Barretta G, Botta M, Botta B, Gulino A, Di Marcotullio L. Infante P, et al. Among authors: di marcotullio l. EMBO J. 2015 Jan 13;34(2):200-17. doi: 10.15252/embj.201489213. Epub 2014 Dec 4. EMBO J. 2015. PMID: 25476449 Free PMC article.
Targeting GLI factors to inhibit the Hedgehog pathway.
Infante P, Alfonsi R, Botta B, Mori M, Di Marcotullio L. Infante P, et al. Among authors: di marcotullio l. Trends Pharmacol Sci. 2015 Aug;36(8):547-58. doi: 10.1016/j.tips.2015.05.006. Epub 2015 Jun 10. Trends Pharmacol Sci. 2015. PMID: 26072120 Review.
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.
Infante P, Alfonsi R, Ingallina C, Quaglio D, Ghirga F, D'Acquarica I, Bernardi F, Di Magno L, Canettieri G, Screpanti I, Gulino A, Botta B, Mori M, Di Marcotullio L. Infante P, et al. Among authors: di marcotullio l, di magno l. Cell Death Dis. 2016 Sep 22;7(9):e2376. doi: 10.1038/cddis.2016.195. Cell Death Dis. 2016. PMID: 27899820 Free PMC article.
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.
Coni S, Mancuso AB, Di Magno L, Sdruscia G, Manni S, Serrao SM, Rotili D, Spiombi E, Bufalieri F, Petroni M, Kusio-Kobialka M, De Smaele E, Ferretti E, Capalbo C, Mai A, Niewiadomski P, Screpanti I, Di Marcotullio L, Canettieri G. Coni S, et al. Among authors: di marcotullio l, di magno l. Sci Rep. 2017 Mar 9;7:44079. doi: 10.1038/srep44079. Sci Rep. 2017. PMID: 28276480 Free PMC article.
Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.
Quaranta R, Pelullo M, Zema S, Nardozza F, Checquolo S, Lauer DM, Bufalieri F, Palermo R, Felli MP, Vacca A, Talora C, Di Marcotullio L, Screpanti I, Bellavia D. Quaranta R, et al. Among authors: di marcotullio l. Cell Death Dis. 2017 Jul 20;8(7):e2942. doi: 10.1038/cddis.2017.326. Cell Death Dis. 2017. PMID: 28726779 Free PMC article.
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.
Calcaterra A, Iovine V, Botta B, Quaglio D, D'Acquarica I, Ciogli A, Iazzetti A, Alfonsi R, Lospinoso Severini L, Infante P, Di Marcotullio L, Mori M, Ghirga F. Calcaterra A, et al. Among authors: di marcotullio l. J Enzyme Inhib Med Chem. 2018 Dec;33(1):349-358. doi: 10.1080/14756366.2017.1419221. J Enzyme Inhib Med Chem. 2018. PMID: 29338454 Free PMC article.
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
Infante P, Faedda R, Bernardi F, Bufalieri F, Lospinoso Severini L, Alfonsi R, Mazzà D, Siler M, Coni S, Po A, Petroni M, Ferretti E, Mori M, De Smaele E, Canettieri G, Capalbo C, Maroder M, Screpanti I, Kool M, Pfister SM, Guardavaccaro D, Gulino A, Di Marcotullio L. Infante P, et al. Among authors: di marcotullio l. Nat Commun. 2018 Mar 7;9(1):976. doi: 10.1038/s41467-018-03339-0. Nat Commun. 2018. PMID: 29515120 Free PMC article.
102 results