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Expedient Synthesis of Lupulones and Their Derivatization to 2,8-7H-Dihydrochromen-7-ones.
ChemistryOpen. 2020 Apr 6;9(4):442-444. doi: 10.1002/open.202000008. eCollection 2020 Apr.
ChemistryOpen. 2020.
PMID: 32269899
Free PMC article.
Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane- or Cycloheptane-Annulated 1,5-Benzothiazepine Scaffold.
De Vreese R, Galle L, Depetter Y, Franceus J, Desmet T, Van Hecke K, Benoy V, Van Den Bosch L, D'hooghe M.
De Vreese R, et al. Among authors: depetter y.
Chemistry. 2017 Jan 1;23(1):128-136. doi: 10.1002/chem.201604167. Epub 2016 Nov 30.
Chemistry. 2017.
PMID: 27717044
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Synthesis and anticancer properties of new (dihydro)pyranonaphthoquinones and their epoxy analogs.
Dang Thi TA, Vu Thi TH, Thi Phuong H, Ha Nguyen T, Pham The C, Vu Duc C, Depetter Y, Van Nguyen T, D'hooghe M.
Dang Thi TA, et al. Among authors: depetter y.
Bioorg Med Chem Lett. 2015 Aug 15;25(16):3355-8. doi: 10.1016/j.bmcl.2015.05.051. Epub 2015 May 28.
Bioorg Med Chem Lett. 2015.
PMID: 26081288
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Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors.
De Vreese R, Depetter Y, Verhaeghe T, Desmet T, Benoy V, Haeck W, Van Den Bosch L, D'hooghe M.
De Vreese R, et al. Among authors: depetter y.
Org Biomol Chem. 2016 Feb 28;14(8):2537-49. doi: 10.1039/c5ob02625c.
Org Biomol Chem. 2016.
PMID: 26822143
Free article.
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Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition.
Depetter Y, Geurs S, Vanden Bussche F, De Vreese R, Franceus J, Desmet T, De Wever O, D'hooghe M.
Depetter Y, et al.
Medchemcomm. 2018 May 18;9(6):1011-1016. doi: 10.1039/c8md00107c. eCollection 2018 Jun 1.
Medchemcomm. 2018.
PMID: 30108990
Free PMC article.
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Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models.
Depetter Y, Geurs S, De Vreese R, Goethals S, Vandoorn E, Laevens A, Steenbrugge J, Meyer E, de Tullio P, Bracke M, D'hooghe M, De Wever O.
Depetter Y, et al.
Int J Cancer. 2019 Aug 1;145(3):735-747. doi: 10.1002/ijc.32169. Epub 2019 Feb 20.
Int J Cancer. 2019.
PMID: 30694564
Free article.
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