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Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.
Kushnir A, Todd JJ, Witherspoon JW, Yuan Q, Reiken S, Lin H, Munce RH, Wajsberg B, Melville Z, Clarke OB, Wedderburn-Pugh K, Wronska A, Razaqyar MS, Chrismer IC, Shelton MO, Mankodi A, Grunseich C, Tarnopolsky MA, Tanji K, Hirano M, Riazi S, Kraeva N, Voermans NC, Gruber A, Allen C, Meilleur KG, Marks AR. Kushnir A, et al. Among authors: clarke ob. Acta Neuropathol. 2020 Jun;139(6):1089-1104. doi: 10.1007/s00401-020-02150-w. Epub 2020 Mar 31. Acta Neuropathol. 2020. PMID: 32236737 Free PMC article.
Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex.
Nygaard R, Graham CLB, Belcher Dufrisne M, Colburn JD, Pepe J, Hydorn MA, Corradi S, Brown CM, Ashraf KU, Vickery ON, Briggs NS, Deering JJ, Kloss B, Botta B, Clarke OB, Columbus L, Dworkin J, Stansfeld PJ, Roper DI, Mancia F. Nygaard R, et al. Among authors: clarke ob. Nat Commun. 2023 Aug 24;14(1):5151. doi: 10.1038/s41467-023-40483-8. Nat Commun. 2023. PMID: 37620344 Free PMC article.
Structure of a mammalian ryanodine receptor.
Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR. Zalk R, et al. Among authors: clarke ob. Nature. 2015 Jan 1;517(7532):44-9. doi: 10.1038/nature13950. Epub 2014 Dec 1. Nature. 2015. PMID: 25470061 Free PMC article.
Structural Basis for Gating and Activation of RyR1.
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J. des Georges A, et al. Among authors: clarke ob. Cell. 2016 Sep 22;167(1):145-157.e17. doi: 10.1016/j.cell.2016.08.075. Cell. 2016. PMID: 27662087 Free PMC article.
Structures of the colossal RyR1 calcium release channel.
Clarke OB, Hendrickson WA. Clarke OB, et al. Curr Opin Struct Biol. 2016 Aug;39:144-152. doi: 10.1016/j.sbi.2016.09.002. Epub 2016 Sep 27. Curr Opin Struct Biol. 2016. PMID: 27687475 Free PMC article. Review.
Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes.
Hartel AJW, Ong P, Schroeder I, Giese MH, Shekar S, Clarke OB, Zalk R, Marks AR, Hendrickson WA, Shepard KL. Hartel AJW, et al. Among authors: clarke ob. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1789-E1798. doi: 10.1073/pnas.1712313115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432144 Free PMC article.
A drug and ATP binding site in type 1 ryanodine receptor.
Melville Z, Dridi H, Yuan Q, Reiken S, Wronska A, Liu Y, Clarke OB, Marks AR. Melville Z, et al. Among authors: clarke ob. Structure. 2022 Jul 7;30(7):1025-1034.e4. doi: 10.1016/j.str.2022.04.010. Epub 2022 May 16. Structure. 2022. PMID: 35580609 Free article.
63 results