Huang PS - Search Results

1

Computational design of closely related proteins that adopt two well-defined but structurally divergent folds.

Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D. Wei KY, et al. Among authors: huang ps. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7208-7215. doi: 10.1073/pnas.1914808117. Epub 2020 Mar 18. Proc Natl Acad Sci U S A. 2020. PMID: 32188784 Free PMC article.

2

Modulation of integrin activation by an entropic spring in the {beta}-knee.

Smagghe BJ, Huang PS, Ban YA, Baker D, Springer TA. Smagghe BJ, et al. Among authors: huang ps. J Biol Chem. 2010 Oct 22;285(43):32954-32966. doi: 10.1074/jbc.M110.145177. Epub 2010 Jul 28. J Biol Chem. 2010. PMID: 20670939 Free PMC article.

3

RosettaRemodel: a generalized framework for flexible backbone protein design.

Huang PS, Ban YE, Richter F, Andre I, Vernon R, Schief WR, Baker D. Huang PS, et al. PLoS One. 2011;6(8):e24109. doi: 10.1371/journal.pone.0024109. Epub 2011 Aug 31. PLoS One. 2011. PMID: 21909381 Free PMC article.

4

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.

Azoitei ML, Correia BE, Ban YE, Carrico C, Kalyuzhniy O, Chen L, Schroeter A, Huang PS, McLellan JS, Kwong PD, Baker D, Strong RK, Schief WR. Azoitei ML, et al. Among authors: huang ps. Science. 2011 Oct 21;334(6054):373-6. doi: 10.1126/science.1209368. Science. 2011. PMID: 22021856

5

High thermodynamic stability of parametrically designed helical bundles.

Huang PS, Oberdorfer G, Xu C, Pei XY, Nannenga BL, Rogers JM, DiMaio F, Gonen T, Luisi B, Baker D. Huang PS, et al. Science. 2014 Oct 24;346(6208):481-485. doi: 10.1126/science.1257481. Science. 2014. PMID: 25342806 Free PMC article.

6

A general computational approach for repeat protein design.

Parmeggiani F, Huang PS, Vorobiev S, Xiao R, Park K, Caprari S, Su M, Seetharaman J, Mao L, Janjua H, Montelione GT, Hunt J, Baker D. Parmeggiani F, et al. Among authors: huang ps. J Mol Biol. 2015 Jan 30;427(2):563-75. doi: 10.1016/j.jmb.2014.11.005. Epub 2014 Nov 14. J Mol Biol. 2015. PMID: 25451037 Free PMC article.

7

Control of repeat-protein curvature by computational protein design.

Park K, Shen BW, Parmeggiani F, Huang PS, Stoddard BL, Baker D. Park K, et al. Among authors: huang ps. Nat Struct Mol Biol. 2015 Feb;22(2):167-74. doi: 10.1038/nsmb.2938. Epub 2015 Jan 12. Nat Struct Mol Biol. 2015. PMID: 25580576 Free PMC article.

8

Computational design and experimental verification of a symmetric protein homodimer.

Mou Y, Huang PS, Hsu FC, Huang SJ, Mayo SL. Mou Y, et al. Among authors: huang ps, huang sj. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10714-9. doi: 10.1073/pnas.1505072112. Epub 2015 Aug 12. Proc Natl Acad Sci U S A. 2015. PMID: 26269568 Free PMC article.

9

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy.

Huang PS, Feldmeier K, Parmeggiani F, Velasco DAF, Höcker B, Baker D. Huang PS, et al. Nat Chem Biol. 2016 Jan;12(1):29-34. doi: 10.1038/nchembio.1966. Epub 2015 Nov 23. Nat Chem Biol. 2016. PMID: 26595462 Free PMC article.

10

Exploring the repeat protein universe through computational protein design.

Brunette TJ, Parmeggiani F, Huang PS, Bhabha G, Ekiert DC, Tsutakawa SE, Hura GL, Tainer JA, Baker D. Brunette TJ, et al. Among authors: huang ps. Nature. 2015 Dec 24;528(7583):580-4. doi: 10.1038/nature16162. Epub 2015 Dec 16. Nature. 2015. PMID: 26675729 Free PMC article.

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