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Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.
Pulvers JN, Bryk J, Fish JL, Wilsch-Bräuninger M, Arai Y, Schreier D, Naumann R, Helppi J, Habermann B, Vogt J, Nitsch R, Tóth A, Enard W, Pääbo S, Huttner WB. Pulvers JN, et al. Among authors: huttner wb. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16595-600. doi: 10.1073/pnas.1010494107. Epub 2010 Sep 7. Proc Natl Acad Sci U S A. 2010. PMID: 20823249 Free PMC article.
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.
Fietz SA, Lachmann R, Brandl H, Kircher M, Samusik N, Schröder R, Lakshmanaperumal N, Henry I, Vogt J, Riehn A, Distler W, Nitsch R, Enard W, Pääbo S, Huttner WB. Fietz SA, et al. Among authors: huttner wb. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11836-41. doi: 10.1073/pnas.1209647109. Epub 2012 Jul 2. Proc Natl Acad Sci U S A. 2012. PMID: 22753484 Free PMC article.
Abnormal spindle-like microcephaly-associated (ASPM) mutations strongly disrupt neocortical structure but spare the hippocampus and long-term memory.
Passemard S, Verloes A, Billette de Villemeur T, Boespflug-Tanguy O, Hernandez K, Laurent M, Isidor B, Alberti C, Pouvreau N, Drunat S, Gérard B, El Ghouzzi V, Gallego J, Elmaleh-Bergès M, Huttner WB, Eliez S, Gressens P, Schaer M. Passemard S, et al. Among authors: huttner wb. Cortex. 2016 Jan;74:158-76. doi: 10.1016/j.cortex.2015.10.010. Epub 2015 Oct 31. Cortex. 2016. PMID: 26691732
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
Gai M, Bianchi FT, Vagnoni C, Vernì F, Bonaccorsi S, Pasquero S, Berto GE, Sgrò F, Chiotto AM, Annaratone L, Sapino A, Bergo A, Landsberger N, Bond J, Huttner WB, Di Cunto F. Gai M, et al. Among authors: huttner wb. EMBO Rep. 2016 Oct;17(10):1396-1409. doi: 10.15252/embr.201541823. Epub 2016 Aug 25. EMBO Rep. 2016. PMID: 27562601 Free PMC article.
On the origin of neurons.
Pulvers JN, Schenk J, Arai Y, Fei JF, Saito K, Huttner WB. Pulvers JN, et al. Among authors: huttner wb. Genome Biol. 2007;8(7):311. doi: 10.1186/gb-2007-8-7-311. Genome Biol. 2007. PMID: 17666121 Free PMC article.
345 results