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Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.
Falls-Hubert KC, Butler AL, Gui K, Anderson M, Li M, Stolwijk JM, Rodman SN 3rd, Solst SR, Tomanek-Chalkley A, Searby CC, Sheffield VC, Sandfort V, Schmidt H, McCormick ML, Wels BR, Allen BG, Buettner GR, Schultz MK, Spitz DR. Falls-Hubert KC, et al. Among authors: schultz mk. Free Radic Biol Med. 2020 Apr;150:1-11. doi: 10.1016/j.freeradbiomed.2020.01.186. Epub 2020 Feb 4. Free Radic Biol Med. 2020. PMID: 32032663 Free PMC article.
O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Shanahan Kauffman EP, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG. Schoenfeld JD, et al. Among authors: schultz mk. Cancer Cell. 2017 Apr 10;31(4):487-500.e8. doi: 10.1016/j.ccell.2017.02.018. Epub 2017 Mar 30. Cancer Cell. 2017. PMID: 28366679 Free PMC article. Clinical Trial.
Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel.
Kloepping KC, Kraus AS, Hedlund DK, Gnade CM, Wagner BA, McCormick ML, Fath MA, Seol D, Lim TH, Buettner GR, Goswami PC, Pigge FC, Spitz DR, Schultz MK. Kloepping KC, et al. Among authors: schultz mk. PLoS One. 2020 Dec 30;15(12):e0244540. doi: 10.1371/journal.pone.0244540. eCollection 2020. PLoS One. 2020. PMID: 33378390 Free PMC article.
N-alkyl triphenylvinylpyridinium conjugated dihydroartemisinin perturbs mitochondrial functions resulting in enhanced cancer versus normal cell toxicity.
Varmazyad M, Modi MM, Kalen AL, Sarsour EH, Wagner B, Du J, Schultz MK, Buettner GR, Pigge FC, Goswami PC. Varmazyad M, et al. Among authors: schultz mk. Free Radic Biol Med. 2021 Mar;165:421-434. doi: 10.1016/j.freeradbiomed.2021.01.050. Epub 2021 Feb 6. Free Radic Biol Med. 2021. PMID: 33561488 Free PMC article.
Structural modifications toward improved lead-203/lead-212 peptide-based image-guided alpha-particle radiopharmaceutical therapies for neuroendocrine tumors.
Lee D, Li M, Liu D, Baumhover NJ, Sagastume EA, Marks BM, Rastogi P, Pigge FC, Menda Y, Johnson FL, Schultz MK. Lee D, et al. Among authors: schultz mk. Eur J Nucl Med Mol Imaging. 2024 Mar;51(4):1147-1162. doi: 10.1007/s00259-023-06494-9. Epub 2023 Nov 13. Eur J Nucl Med Mol Imaging. 2024. PMID: 37955792 Free PMC article.
Synthesis and Evaluation of Tetraarylethylene-based Mono-, Bis-, and Tris(pyridinium) Derivatives for Image-Guided Mitochondria-Specific Targeting and Cytotoxicity of Metastatic Melanoma Cells.
Reedy JL, Hedlund DK, Gabr MT, Henning GM, Pigge FC, Schultz MK. Reedy JL, et al. Among authors: schultz mk. Bioconjug Chem. 2016 Oct 19;27(10):2424-2430. doi: 10.1021/acs.bioconjchem.6b00394. Epub 2016 Sep 23. Bioconjug Chem. 2016. PMID: 27643916 Free PMC article.
Automated cassette-based production of high specific activity [203/212Pb]peptide-based theranostic radiopharmaceuticals for image-guided radionuclide therapy for cancer.
Li M, Zhang X, Quinn TP, Lee D, Liu D, Kunkel F, Zimmerman BE, McAlister D, Olewein K, Menda Y, Mirzadeh S, Copping R, Johnson FL, Schultz MK. Li M, et al. Among authors: schultz mk. Appl Radiat Isot. 2017 Sep;127:52-60. doi: 10.1016/j.apradiso.2017.05.006. Epub 2017 May 10. Appl Radiat Isot. 2017. PMID: 28521118 Free PMC article.
O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Kauffman EPS, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG. Schoenfeld JD, et al. Among authors: schultz mk. Cancer Cell. 2017 Aug 14;32(2):268. doi: 10.1016/j.ccell.2017.07.008. Cancer Cell. 2017. PMID: 28810149 Free article. No abstract available.
81 results