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Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.
Biochemistry. 2020 Feb 18;59(6):736-741. doi: 10.1021/acs.biochem.0c00013. Epub 2020 Feb 4.
Biochemistry. 2020.
PMID: 32013401
Free PMC article.
Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism.
Ciulla DA , Wagner AG , Liu X , Cooper CL , Jorgensen MT , Wang C , Goyal P , Banavali NK , Pezzullo JL , Giner JL , Callahan BP .
Ciulla DA , et al. Among authors: pezzullo jl.
Chem Commun (Camb). 2019 Feb 5;55(12):1829-1832. doi: 10.1039/c8cc09729a.
Chem Commun (Camb). 2019.
PMID: 30672911
Free PMC article.
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Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition.
Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Kandel N, Giner JL, Covey DF, Wang C, Callahan BP.
Wagner AG, et al. Among authors: pezzullo jl.
Biochemistry. 2022 Jun 7;61(11):1022-1028. doi: 10.1021/acs.biochem.1c00697. Epub 2021 Dec 23.
Biochemistry. 2022.
PMID: 34941260
Free PMC article.
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A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators.
Ciulla DA, Dranchak P, Pezzullo JL, Mancusi RA, Psaras AM, Rai G, Giner JL, Inglese J, Callahan BP.
Ciulla DA, et al. Among authors: pezzullo jl.
J Biol Chem. 2022 Dec;298(12):102705. doi: 10.1016/j.jbc.2022.102705. Epub 2022 Nov 16.
J Biol Chem. 2022.
PMID: 36400200
Free PMC article.
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Paracatalytic induction: Subverting specificity in hedgehog protein autoprocessing with small molecules.
Ciulla DA, Xu Z, Pezzullo JL, Dranchak P, Wang C, Giner JL, Inglese J, Callahan BP.
Ciulla DA, et al. Among authors: pezzullo jl.
Methods Enzymol. 2023;685:1-41. doi: 10.1016/bs.mie.2023.03.001. Epub 2023 Apr 19.
Methods Enzymol. 2023.
PMID: 37245899
Free PMC article.
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