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The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau.
Shen LL, Mañucat-Tan NB, Gao SH, Li WW, Zeng F, Zhu C, Wang J, Bu XL, Liu YH, Gao CY, Xu ZQ, Bobrovskaya L, Lei P, Yu JT, Song W, Zhou HD, Yao XQ, Zhou XF, Wang YJ. Shen LL, et al. Among authors: zhou xf, zhou hd. Mol Psychiatry. 2018 Aug;23(8):1813-1824. doi: 10.1038/s41380-018-0071-z. Epub 2018 Jun 4. Mol Psychiatry. 2018. PMID: 29867188
Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor.
Saadipour K, Tiberi A, Lombardo S, Grajales E, Montroull L, Mañucat-Tan NB, LaFrancois J, Cammer M, Mathews PM, Scharfman HE, Liao FF, Friedman WJ, Zhou XF, Tesco G, Chao MV. Saadipour K, et al. Among authors: zhou xf. Mol Cell Neurosci. 2019 Sep;99:103395. doi: 10.1016/j.mcn.2019.103395. Epub 2019 Aug 15. Mol Cell Neurosci. 2019. PMID: 31422108 Free PMC article.
651 results