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Yeast as a model for studying Alzheimer's disease.
Bharadwaj P, Martins R, Macreadie I. Bharadwaj P, et al. FEMS Yeast Res. 2010 Dec;10(8):961-9. doi: 10.1111/j.1567-1364.2010.00658.x. FEMS Yeast Res. 2010. PMID: 20618869 Review.
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. Steele JW, et al. Among authors: martins rn. Mol Psychiatry. 2013 Aug;18(8):889-97. doi: 10.1038/mp.2012.106. Epub 2012 Jul 31. Mol Psychiatry. 2013. PMID: 22850627 Free PMC article.
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S. Steele JW, et al. Among authors: martins rn. Mol Psychiatry. 2013 Aug;18(8):882-8. doi: 10.1038/mp.2012.115. Epub 2012 Aug 7. Mol Psychiatry. 2013. PMID: 22869031 Free PMC article.
Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.
Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, Martins RN. Bharadwaj PR, et al. Among authors: martins rn. J Alzheimers Dis. 2012;32(4):949-67. doi: 10.3233/JAD-2012-120178. J Alzheimers Dis. 2012. PMID: 22903131 Free PMC article.
The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity.
Porter T, Bharadwaj P, Groth D, Paxman A, Laws SM, Martins RN, Verdile G. Porter T, et al. Among authors: martins rn. J Alzheimers Dis. 2016;50(3):895-905. doi: 10.3233/JAD-150790. J Alzheimers Dis. 2016. PMID: 26836170 Free PMC article.
Cerebral amyloid-β accumulation and deposition following traumatic brain injury--A narrative review and meta-analysis of animal studies.
Bird SM, Sohrabi HR, Sutton TA, Weinborn M, Rainey-Smith SR, Brown B, Patterson L, Taddei K, Gupta V, Carruthers M, Lenzo N, Knuckey N, Bucks RS, Verdile G, Martins RN. Bird SM, et al. Among authors: martins rn. Neurosci Biobehav Rev. 2016 May;64:215-28. doi: 10.1016/j.neubiorev.2016.01.004. Epub 2016 Feb 17. Neurosci Biobehav Rev. 2016. PMID: 26899257 Review.
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